Lower leg heat therapy via water immersion up to the knee in a circulated bath (water temperature 42°C, 4 times per week, 45 minutes per session) for 8 weeks.

Lower leg immerse in a thermoneutral water bath (33°C), 4 times per week, 45 minutes per session for 8 weeks.

Essential Hypertension

All subjects in this research project will be women by design. Women between the ages of 65 and 85 years old will be enrolled.

Home-based 8 weeks of lower leg repeated heating.

Lower leg heat therapy

Institute for Exercise and Environmental Medicine

Heat Therapy in Older Hypertensive Women

Chronic Lower Leg Heating for the Treatment of Hypertension in Older Women

24-hour ambulatory blood pressure monitoring will be performed and systolic blood pressure during the awake period before and after treatment will be compared in older women with hypertension.

We will us the microneurographic technique to measure muscle sympathetic nerve activity in all older hypertensive women before and after treatment. Results will be compared between the intervention group and the control group.

We will use the Ultrasound Doppler technique to measure vascular function including arterial stiffness and endothelial function in older hypertension women before and after treatment. Results will be compared between the groups.

The PD/PIs will comply with the NIH policy of data sharing. Our goal is to make all our data available as quickly as possible to the scientific community. The privacy and rights of the participants will be protected. To address this goal, a Data Sharing Committee will be formed, made up of the two PIs and the statistician.
5) Researchers will make written application to the Data Sharing Committee, and once approved, data will be provided via a secure DropBox or ftp site.

University of Texas Southwestern Medical Center

This is a randomized, placebo-controlled study. Older women with hypertension will randomly be assigned to either an intervention group or a control group (1:1 ratio). Patients in the intervention group will be required to perform 8 weeks of home-based lower leg heat therapy via water immersion up to the knee in a circulated bath (water temperature 42°C, 4 times per week, 45 min per session), whereas patients in the control group will immerse their legs in a thermoneutral water bath (33°C) at the same frequency and duration.

The randomization will be programmed with SAS Proc Plan and implemented via a user friendly web-based interface using REDCap. The biostatistician will be responsible for randomization; however, he/she will not have any contact with the patients and will not be involved in outcome measures. All investigators, except the research nurses, will be blinded to the group status of the patient during 8-week treatment and post-treatment testing. The research nurses will not be involved in data analysis and interpretation.

Cutaneous Leishmaniasis

daily nitric oxide patch application during 20 days

controlled nitric oxide releasing patch

meglumine antimoniate

Fundación Cardiovascular de Colombia

Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

Double Blind, Randomized Controlled Trial, to Evaluate the Effectiveness of a Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

l arginine/náusea

Heat Therapy in Older Hypertensive Women

Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

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