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The Binding of Silibinin, the Main Constituent of Silymarin, to Site I on Human Serum Albumin.
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Silibinin is the main constituent of silymarin, an extract from the seeds of milk thistle (Silybum marianum). Because silibinin has many pharmacological activities, extending its clinical use in the treatment of a wider variety of diseases would be desirable. In this study, we report on the binding
Effects of long-term silymarin oral supplementation on the blood biochemical profile of rainbow trout (Oncorhynchus mykiss).
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Silymarin, an extract from "milk thistle" (Silybum marianum) plant is traditionally used as herbal medicine. The present study was conducted to investigate the clinical effects and possible side effects of silymarin on biochemical blood parameters of rainbow trout (Oncorhynchus mykiss). Fishes were
The protective effect of silymarin on the carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio).
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Silymarin, a mixture of bioactive flavonolignans from the milk thistle (Silybum marianum), is traditionally used in herbal medicine to defend against various hepatotoxic agents. The aim of the present study was to evaluate the protective effect of silymarin against carbon tetrachloride
Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy.
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Legalon SIL (SIL) is a chemically hydrophilized version of silibinin, an extract of milk thistle (Silybum marianum) seeds that has exhibited hepatoprotective and antiviral effectiveness against hepatitis C virus (HCV) in patients leading to viral clearance in combination with ribavirin. To elucidate
Milk thistle for the treatment of liver disease: a systematic review and meta-analysis.
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OBJECTIVE
Milk thistle, an herbal compound, is the dietary supplement taken most frequently by patients with chronic liver disease. We performed a systematic review of the literature to determine the efficacy and safety of this herb for the treatment of liver disease.
METHODS
We searched English and
Policosanol composition, antioxidant and anti-arthritic activities of milk thistle (Silybium marianum L.) oil at different seed maturity stages.
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BACKGROUND
Several anti-arthritic drugs and synthetic antioxidants have wide pharmaceutical uses and are often associated with various side effects on the human health. Dietary seed oils and their minor components like policosanol may offer an effective alternative treatment for arthritic and
Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage.
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Silymarin is a complex mixture of four flavonolignan isomers (silybin, isosilybin, silydianin and silychristin) obtained from 'milk thistle' (Silybum marianum). This plant compound is used almost exclusively for hepatoprotection. Because of its low and poor oral bioavailability, silymarin was
The effects of milk thistle on hepatic fibrosis due to methotrexate in rat.
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BACKGROUND
Extracts of milk thistle (MT), Silybum marianum, have been used as medical remedies since the time of ancient Greece. Methotrexate is a potentially hepatotxic drug.
OBJECTIVE
To clarify the hepatoprotective effects of MT on methotrexate.
METHODS
From January 2010 to April 2010, 30 male
Hepatoprotective role of Legalon 70 against hydrogen peroxide in chickens.
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Objectives
This study aimed at evaluating the effect of Legalon 70, a standard hepatic drug of silymarin, in reducing the toxic effects of hydrogen peroxide (H2O2) in broiler chickens.Methods
Twenty Ross broiler chickens of 30-day oldLa base de datos de hierbas medicinales más completa respaldada por la ciencia
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