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Overweight and Obesity as Prognostic Factors for Survival in Children With Acute Lymphoblastic Leukemia
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Data collection Information regarding sex, age at diagnosis, place of residence, white blood cell (WBC) count, immunophenotype (B or T lineage), weight and height (length when appropriate) at diagnosis, and chemotherapy protocol is collected from the patients' clinical charts by previously
Dietary Intake, Sarcopenic Obesity, and Other Treatment-Related Outcomes in Indian Children With Acute Lymphoblastic Leukemia
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Survival of childhood ALL exceeds 80% in an increasing number of many low-middle income countries (LMIC). Recent studies have found that the effects of obesity on survival are observed within the first several years of diagnosis, thus impacting immediate health outcome. Of concern is the developing
Metabolic Syndrome in Childhood Cancer Survivors
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Brief Overview:
The remarkable progress in developing curative therapy for childhood cancer over the last 4 to 5 decades has increased awareness of the serious cancer treatment-related late effects experienced by long-term survivors such as premature mortality early deaths, second primary cancers,
Effects of Exercises on Total Body Health in Children With Acute Lymphoblastic Leukemia
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Treatment and intervention options are being tried to avoid such complications that affect the quality of life of patients and there is still no standard treatment to convert bone health to healthy bone structure before the disease. There is a positive effect of improving the bone health of the
Role of Sleep Apnea in the Neuropsychological Function in Down Syndrome People
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Down Syndrome (DS) is the most common cause of mental retardation with incidence of 1 in 848 (Lin, Hu et al. 1991). Although prenatal Down syndrome and Amniocentesis had been applied for years, in the survey of 2005, current birth incidence of DS is 1.6 in 10,000 live birth, meaning a 30-50 new
Low GI Diet in Children and Adolescents With ALL
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Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy with survival exceeding 90%. However, treatment-related toxicity remains a clinical challenge during and after treatment. Evidence-based, nutritional interventions may minimize the development of nutrition-related toxicities,
Signal Detection in Monoclonal and New Agents in Lymphoma
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The French public healthcare system perspective developed a unique SNIIR-AM (interregimens National Information Health Insurance system.) data base that contains up to 18 TeraOctet of medical consumption data (consultations, exams and drug prescriptions and hospitalization, yes/no). Its main
Improving Diet and Exercise in Acute Lymphoblastic Leukemia (IDEAL Weight in ALL)
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In our previous study, we have observed that: 1) nearly half ALL patients are overweight or obese at diagnosis, 2) all patients, regardless of starting weight, gain significant fat mass over the first month of therapy (on average 20-30%), and 3) obesity at the time of diagnosis is associated with a
The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43
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Research Plan:
Patients without gastrointestinal symptoms scheduled for a screening or surveillance colonoscopy (for colorectal cancer) at the UCH endoscopy lab will be screened for the study based on the inclusion and exclusion criteria. Eligible patients who consent to the study will have height,
Faecal Microbiota Transplantation in Irritable Bowel Syndrome
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1. Background
Irritable bowel syndrome (IBS) is a chronic, debilitating, functional gastrointestinal disorder with estimated population prevalence in Europe between of 10 -15% (Ford et al). These symptoms can be debilitating and lead to a significant reduction in quality of life particularly in the
Exercise and QUality Diet After Leukemia: The EQUAL Study
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Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
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PRIMARY OBJECTIVES:
I. To evaluate the effect of clofarabine induction and consolidation therapy on overall survival in comparison with standard therapy (daunorubicin [daunorubicin hydrochloride] & cytarabine) in newly-diagnosed acute myeloid leukemia (AML) patients age >= 60 years.
SECONDARY
ALL-Active: A Family-Based Lifestyle Program for Pediatric Acute Leukemia Patients
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PRIMARY OBJECTIVES:
I. To evaluate feasibility, adherence, completion rates and participant satisfaction associated with a family based lifestyle intervention for overweight pediatric acute lymphoblastic leukemia (ALL) patients or those at high risk to become so (body mass index [BMI] >= 50th
A Randomized Study of Iodine-131 Anti-b1 Antibody Versus Anti-b1 Antibody in Chemotherapy-relapsed/Refractory Low-grade or Transformed Low-grade Non-Hodgkin's Lymphoma (NHL)
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This is a Phase II randomized, controlled, two-arm, open-label, multicenter study comparing the safety and efficacy of tositumomab and iodine I 131 tositumomab to tositumomab for the treatment of chemotherapy-relapsed or refractory low-grade or transformed low-grade B-cell NHL.
Treatment Arm A:
Steroid Treatment of Idiopathic Nephrotic Syndrome
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Background Idiopathic nephrotic syndrome (INS) is the most frequent glomerular disease in childhood, with an incidence of 2-4 cases per 100,000 children. Currently, all children with INS are treated at onset with steroids. Approximately 80% of cases respond to oral corticosteroid therapy, but 75-80%
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