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N(epsilon)(carboxymethyl)lysin and the AGE receptor RAGE colocalize in age-related macular degeneration.
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OBJECTIVE
To investigate whether glycoxidation products and the receptor for advanced glycation end products (RAGE) are present and colocalize in subfoveal membranes of patients with age-related macular degeneration (ARMD).
METHODS
Surgically removed subfoveal fibrovascular membranes from 12
THE CHEMISTRY OF THE LIVER IN ACUTE YELLOW ATROPHY.
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From the liver of a young man who died of typical, " idiopathic" acute yellow atrophy of the liver, after an illness of six weeks, there were isolated and identified the following amino acids: Histidin, lysin, tyrosin, leucin, glycocoll, alanin, prolin, glutaminic acid, aspartic acid. These were
ON THE HEXON BASES OF LIVER TISSUE UNDER NORMAL AND CERTAIN PATHOLOGICAL CONDITIONS.
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The results above reported lead to the conclusion that while in the degenerating cells chemical changes are taking place tending toward a diminution of the hexon bases as a whole, they affect the arginin especially. One may picture the process either as a partial or as a complete breaking down of
EXPERIMENTAL LIVER NECROSIS; I. THE HEXON BASES.
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1. The liver of the dog in which necrosis has been produced by injection of haematoxic immune sera is characterized in the less marked forms by a storing up of nitrogen in the persisting living cells, while in the diffuse forms the total nitrogen content is but slightly above the normal. This last
STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : IV. STREPTOLYSIN.
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The "spontaneous deterioration" of streptolysin has been studied by the methods already used in investigations of the oxidation-reduction of blood pigments and of the lysins of other bacteria. From the results of this study, it may be concluded that the commonly observed "spontaneous deterioration"
STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : IV. CONCERNING THE ONENESS OF THE BACTERIOPHAGE.
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Lytic filtrates, active against Bacillus dysenterioe Shiga, Bacillus coli, Bacillus pestis cavioe, and staphylococcus respectively, proved to be differently affected by changes in hydrogen ion concentration. Anti-staphylococcus lysin was the least resistant of the four, showing deterioration in 3
Arginine-containing compounds and thymic endocrine activity.
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The frequent association of malnutrition, infectious disease and aging has stressed the role played by some nutrients on the immune efficiency and particularly on the age-dependent immunological decline. Since arginine has been proven to enhance immune efficiency as demonstrated by the observation
Association between oxidative stress and microRNA expression pattern of ALS patients in the high-incidence area of the Kii Peninsula
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Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disorder of the upper and lower motor neuron systems. The high incidence of ALS in the southern part of the Kii Peninsula of Japan (K-ALS) was reported in the 1960s, but it has gradually decreased to the worldwide average. Although
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