malate dehydrogenase/cansancio

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Fatigue of rat hindlimb motor units: biochemical-physiological associations.

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Associations between fatigability and biochemical properties within motor unit (MU) types were explored in two hindlimb muscles of the adult rat. Type FF MUs in extensor digitorum longus and type S units in soleus were subjected either to a moderate (type FF) or severe (type S) 6-min,

Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome.

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Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by unexplained fatigue not improved by rest. An area of investigation is the likely connection of CFS with defective mitochondrial function. In a previous work, we investigated the proteomic salivary profile in a

Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice.

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L-malate, a tricarboxylic acid cycle (TCA) intermediate, plays an important role in transporting NADH from cytosol to mitochondria for energy production and may be involved in the beneficial effects of improving physical stamina. In the present study, we investigated the effects of L-malate on the

Comparison of enzyme activities among single muscle fibres within defined motor units.

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1. Muscle fibres from single motor units of rat extensor digitorum longus were depleted of their glycogen by electrical stimulation and identified by the periodic acid-Schiff stain after treatment in a medium that selectively enhanced glycogen content in the non-depleted fibres. 2. Malate

[Change in gastrocnemius dystrophin and metabolic enzymes and increase in high-speed exhaustive time induced by hypoxic training in rats].

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The aim of the present study was to explore the changes and roles of dystrophin and membrane permeability in hypoxic training. Seventy-two 8-week-old Sprague Dawley (SD) rats were randomly divided into 4 groups, normoxic non-train (NC), normoxic train (NT), hypoxic non-train (HC), and hypoxic train

Sexual differences and steroid-induced changes in metabolic activity in toadfish sonic muscle.

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Since the male oyster toadfish (Opsanus tau) is more active in sound production than the female, we hypothesized that sonic muscles of the male are biochemically specialized to perform more work. In order to categorize the muscle biochemically and test for sexual differences, we measured the

Adaptive Changes After 2 Weeks of 10-s Sprint Interval Training With Various Recovery Times.

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Purpose: The aim of this study was to compare the effect of applying two different rest recovery times in a 10-s sprint interval training session on aerobic and anaerobic capacities as well as skeletal muscle enzyme activities. Methods: Fourteen physically active but not highly trained male subjects

Skeletal muscle oxidative capacity and exercise tolerance in rats with heart failure.

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OBJECTIVE Past research has shown the development of exercise intolerance after myocardial infarction (MI). The purpose of this study was to test the hypothesis that reductions in oxidative enzyme activity, in a variety of skeletal muscles, coincide with the development of exercise intolerance in a

Antifatigue Effects of Anshenyizhi Compound in Acute Excise-Treated Mouse via Modulation of AMPK/PGC-1α-related Energy Metabolism and Nrf2/ARE-mediated Oxidative Stress

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The anshenyizhi compound (AC), a mixture from Chinese medicine herbs, has numerous biological effects. In the present study, the acute exercise-treated mice model was established to explore the antifatigue properties of AC and its underlying mechanisms. AC increased exercise endurance in the

Energetic metabolism and fatigability in experimental myotonia.

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Experimental myotonia was induced in rats by 2,4-dichloro-phenoxyacetic acid (2,4-D). After 4 to 24 h of treatment, the anterior tibialis muscles exhibited increased fatigue at low frequency (30 Hz) nerve stimulation, but they developed normal tension at high-frequency (100 Hz) stimulation. Glycogen

Association between biochemical and physiological properties in single motor units.

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Motor units from the cat tibialis posterior muscle were examined for an association between physiological and biochemical properties. Functionally isolated motor units were categorized on the basis of their physiological properties. This was followed by quantitative microbiochemical analysis of

[Biochemical changes in skeletal muscles after chronic indirect stimulation].

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The skeletal muscle has the capacity to respond adaptively to increased use. This observation could open up the feasibility of constructing pumping chambers to support or even replace cardiac work. We investigated the changes in enzyme activity due to chronic stimulation in an animal skeletal

Systematic analysis of the cerebrospinal fluid proteome of fibromyalgia patients.

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Fibromyalgia (FM) is a syndrome characterized by widespread muscular pain, fatigue and functional symptoms, which is known to be difficult to diagnose as the various symptoms overlap with many other conditions. Currently, there are no biomarkers for FM, and the diagnosis is made subjectively by the

Grape seed proanthocyanidin extract promotes skeletal muscle fiber type transformation via AMPK signaling pathway

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Transformation of skeletal muscle fiber type from fast twitch to slow twitch has significances for sustained contractile and stretchable events, energy homeostasis and antifatigue ability. However, the regulation of skeletal muscle fiber type transformation through nutritional intervention is still

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