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malate dehydrogenase/hypoxia
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Changes in lactate dehydrogenase and malate dehydrogenase activities during hypoxia and after temperature acclimation in the armored fish, Rhinelepis strigosa (Siluriformes, Loricariidae).
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Lactate (LDH) and malate dehydrogenase (MDH) of white skeletal muscle of fishes acclimated to 20, 25 and 30 degrees C and thereafter submitted to hypoxia were studied in different substrate concentrations. Significant differences for LDH and MDH of white muscle enzyme activities are described here
Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors.
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A structure-activity relationship study of hypoxia inducible factor-1α inhibitor 3-aminobenzoic acid-based chemical probes, which were previously identified to bind to mitochondrial malate dehydrogenase 2, was performed to provide a better understanding of the pharmacological effects of LW6 and its
[The role of malate dehydrogenase in adaptation to hypoxia in invertebrates].
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In muscle tissue of lamellibranch molluscs and crustaceans (cf. Table for the species studied), high levels of malate dehydrogenase and low ones of lactade dehydrogenase were detected. There is a direct relationship between the value of MDH/LDH ratio and the capacity of organisms to withstand
A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration.
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We previously reported that hypoxia-inducible factor (HIF)-1 inhibitor LW6, an aryloxyacetylamino benzoic acid derivative, inhibits malate dehydrogenase 2 (MDH2) activity during the mitochondrial tricarboxylic acid (TCA) cycle. In this study, we present a novel MDH2 inhibitor compound 7 containing
[Effect of hydrocortisone and insulin on the activity and isoenzyme spectrum of NAD-dependent malate dehydrogenase in the lungs, liver and cortical layer of the kidneys of rats with acute hypoxia].
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[Effect of hypoxia on the activity of malate dehydrogenase isoenzymes in newborn rabbits].
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[Isocitrate dehydrogenase and malate dehydrogenase activity in tissues of rats with different degrees of resistance to acute hypoxic hypoxia].
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Proteomic analysis of hypoxia-induced responses in the syncytialization of human placental cell line BeWo.
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Syncytiotrophoblast formation is affected by a number of pathological conditions and suppressed syncytiotrophoblast formation due to hypoxia may play a role in the pathogenesis of preeclampsia. However, the molecular basis of hypoxia-inhibited trophoblast syncytialization is poorly understood. To
Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.
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Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the present study was to evaluate the effects of Krebs' cycle inhibition at the level
Proteomic analysis of the mouse brain after repetitive exposure to hypoxia.
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Hypoxic preconditioning (HPC) is known to have a protective effect against hypoxic damage; however, the precise mechanisms involved remain unknown. In this study, an acute and repetitive hypoxia mouse model, two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) coupled with
[Study on the content of myoglobin and the activity of lactate dehydrogenase and malate dehydrogenase in skeletal muscle of tibetan antelope].
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OBJECTIVE
To explore the adaptive mechanism to hypoxia in skeletal muscle of tibetan antelope.
METHODS
Tibetan sheep which living at the same altitude (4 300 m) with tibetan antelope and low altitude (1 800 m) sheep as control, the content of myoglobin (Mb) and lactic acid (LA), the activity of
Effect of transient hypoxia in skeletal muscle on enzyme activities in lymph and plasma.
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The effect of hypoxia lasting one hour on the hind leg muscle of anaesthetised dogs was investigated. Ten enzyme activities in plasma and leg lymph, and the lymphatic transport of these enzymes were investigated. Enzymes with high activity in muscle, like creatine kinase, lactate dehydrogenase,
Effect of hypoxia on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells.
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We have studied the effect of hypoxia on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells under the inhibition of IRE1 (inositol requiring enzyme-1), which controls cell proliferation and tumor growth as a central mediator of endoplasmic reticulum stress. It was
Effects of hypoxia on enzyme activities in skeletal muscle of rats of different ages. An attempt at pharmacological treatment.
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The activities of enzymes related to energy metabolism in the gastrocnemius and soleus muscles in young-adult (4 months), mature (12 months) and senescent (24 months) rats were compared after 72 h of continuous exposure to normobaric hypoxia or normoxia after alpha-adrenergic antagonist nicergoline
Hopantenate interference on the adaptation of muscular energy metabolism to intermittent hypoxia.
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In rat gastrocnemius muscle, the concentrations of glycolytic fuels, intermediates and end-products; Krebs cycle intermediates and related free amino acids; ammonia; energy store and mediators; and the energy charge potential were evaluated in normoxia or after repeated, alternate hypoxic and
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