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migraine disorders/vómito
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Pharmaceutical compositions for headache, migraine, nausea and emesis
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FIELD OF THE INVENTION
The present invention relates to the use of S-alkylisothiouronium derivatives, including, but not limited to, S-ethylisothiouronium diethylphosphate, for the prevention or treatment of headache, including but not limited to migraine, and for the prevention or treatment of
Pharmaceutical compositions for headache, migraine, nausea and emesis
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FIELD OF THE INVENTION
The present invention relates to the use of S-alkylisothiouronium derivatives, including, but not limited to, S-ethylisothiouronium diethylphosphate, for the prevention or treatment of headache, including but not limited to migraine, and for the prevention or treatment of
Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis
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This invention relates to novel compounds having useful pharmacological properties, to pharmaceutical compositions containing them, to a process and intermediates for their preparation, and to their use as pharmaceuticals.
UK Patent Applications, GB Nos. 2100259A and 2125398A describe benzoates and
Indolyl carboxamides useful treating migraine, cluster headache, trigeminal neuralgia or emesis
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This invention relates to novel compounds having useful pharmacological properties, to pharmaceutical compositions containing them, to a process and intermediates for their preparation, and to their use as pharmaceuticals.
The compound, N-(1-azabicyclo[2.2.2]oct-3-yl)-2,3-dihydroindole-1-carboxylic
Indole derivatives in the treatment of emesis
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This invention relates to the use of certain indole derivatives in the treatment or prevention of emesis.
International Patent Application WO 92/06973 discloses a series of indole derivatives which are potent serotonin (5-HT.sub.1) agonists. These compounds are useful for treating disorders arising
Multisymptom migraine combination medication
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BACKGROUND OF THE INVENTION
In the United States, more than 37 million people suffer from migraines. Migraines are associated with decreased productivity and have a deleterious effect on quality of life. It is estimated that the total cost of lost productive time due to migraines is 19.6 billion.
Treatment of emesis with morpholine tachykinin receptor antagonists
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SUMMARY OF THE INVENTION
This invention is concerned with novel compounds represented by structural formula I: ##STR2## wherein R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.11, R.sup.12, R.sup.13, A, B, p, Y and Z are hereinafter defined.
The invention is also concerned with pharmaceutical
Treatment of migraine with morpholine tachykinin receptor antagonists
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SUMMARY OF THE INVENTION
This invention is concerned with novel compounds represented by structural formula I: ##STR2## wherein R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.11, R.sup.12, R.sup.13, A, B, p, Y and Z are hereinafter defined.
The invention is also concerned with pharmaceutical
Methods for treating emesis and nausea using optically pure R(+) ondansetron
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BACKGROUND OF THE INVENTION
This invention relates to novel compositions of matter containing optically pure R(+) ondansetron. These novel compositions have potent antiemetic activity and are useful in ameliorating the nausea and vomiting otherwise induced by cancer chemotherapeutic agents and
Treatment of migraine, cluster headaches and trigeminal neuralgia
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This invention relates to a method of treatment of migraine, cluster headaches and trigeminal neuralgia, radiation or cytotoxic agent induced nausea and vomiting and/or cardiac arrhythmia in mammals, including humans, and to the use of compounds in the preparation of a medicament for the treatment
Benzoimidazole derivatives and pharmaceutical composition comprising the same
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TECHNICAL FIELD
The present invention relates, in general, to novel benzoimidazole derivatives and, more particularly, to novel benzoimidazole derivatives functioning as antagonists to a vanilloid receptor (capsaicin receptor; Transient Receptor Potential Channel, Vanilloid subfamily member 1;
Five-membered ring systems with bonded imidazolyl ring substituents
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This invention relates to a class of 5-membered heterocyclic compounds having at least one heteroatom, which are useful in the treatment of psychotic disorders (e.g. schizophrenia and mania); anxiety; alcohol or drug withdrawal or dependence; pain; gastric stasis; gastric dysfunction (such as occurs
Benzisoxazole derivatives
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BACKGROUND OF THE INVENTION
This invention relates to benzisoxazole derivatives. These compounds have selective 5-HT.sub.4 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives for the treatment
Indazole derivatives
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BACKGROUND OF THE INVENTION
This invention relates to Indazole Derivatives. These compounds have selective 5-HT.sub.4 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives for the treatment of
Oxyindole derivatives
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BACKGROUND OF THE INVENTION
This invention relates to Oxyindole Derivatives. These compounds have selective 5-HT.sub.4 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives for the treatment of
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