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multiple endocrine neoplasia type 1/obesidad

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A Novel Missense Mutation of the MEN1 Gene in a Patient with Multiple Endocrine Neoplasia Type 1 with Glucagonoma and Obesity.

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A 35-year-old obese diabetic man presented with recurrent primary hyperparathyroidism during a three-year outpatient follow-up. He was clinically diagnosed with multiple endocrine neoplasia type 1 (MEN1) due to the presence of a pituitary adenoma and multiple glucagonomas. The glucagonomas may have

Two familial giant pituitary adenomas associated with overweight: clinical, morphological and genetic features.

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OBJECTIVE Pituitary adenomas are usually sporadic, although rare familial cases have been described. Here we report two first degree female cousins with giant pituitary adenoma and overweight. Both presented with secondary amenorrhoea, occasional headache and weight gain. METHODS In both patients

Effects of secretin on the normal and pathological beta-cell.

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Secretin is a gastrointestinal hormone that stimulates insulin secretion and enhances the insulin response to glucose. The mechanism by which secretin acts on the beta-cell has not been extensively studied. The plasma insulin responses to secretin (2 U/kg), expressed as the percent increase relative

Update on secondary forms of hyperparathyroidism.

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Recent information has shed a new light on the control of parathyroid hormone (PTH) secretion by calcium and 1,25-(OH)2D. These new data have permitted a better understanding of the pathogenesis and management of secondary hyperparathyroidism in end-stage renal disease. Emerging evidence has

Multiple endocrine neoplasia and polyglandular autoimmune syndrome: a new association.

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OBJECTIVE To report a new association between polyglandular autoimmune syndrome and multiple endocrine neoplasia. METHODS We present a detailed case report and discuss the various types of polyglandular failure and multiple endocrine neoplasia. RESULTS A 56-year-old woman with a past history of

Molecular genetic testing in endocrinology - a practical guide.

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OBJECTIVE To discuss the factors to consider when evaluating patients with a suspected genetic endocrine disorder, so as to guide practicing endocrinologists through the process of genetic testing and result interpretation. METHODS The author's experience and review of appropriate literature have
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