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6 resultados
Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells.
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Hypoxia-inducible factor-1 (HIF-1) is an important tumor-selective therapeutic target for solid tumors. Icariside II was isolated from Epimedium koreanum through successive fractionation with ethyl acetate, n-butanol, chloroform and hexane, followed by gel column chromatography. Icariside II
Pharmacodynamic screening and simulation study of anti-hypoxia active fraction of xiangdan injection.
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BACKGROUND
The herbal formula Xiangdan injection and its modifications have been used in traditional Chinese medicine for about hundreds years to alleviate pain and promoting blood.
OBJECTIVE
To investigate the anti-hypoxia active fraction of Xiangdan injection.
METHODS
Xiangdan injection was
Antioxidant potential, total phenolic and total flavonoid contents of Rhododendron anthopogonoides and its protective effect on hypoxia-induced injury in PC12 cells.
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BACKGROUND
Rhododendron anthopogonoides Maxim, a kind of traditional Tibetan medicine, has been used to remove body heat, body detoxification, cough, asthma, stomachic and swelling, eliminate abundant phlegm and inflammatory for a long time. In the present study, the total phenols and total
Bladder outlet obstruction accelerates bladder carcinogenesis.
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OBJECTIVE
To examine the correlation between partial bladder outlet obstruction (PBOO) and bladder carcinogenesis.
METHODS
Female Wistar rats (6 weeks old) were divided into three groups of 10 each: group 1 was exposed to n-butyl-n-butanol nitrosamine (BBN, a carcinogen) in drinking water for 8
Adaptation of olfactory threshold at high altitude.
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The aim of this study was to investigate the effects of the extreme environment of high altitude hypoxia on olfactory threshold. The study was conducted before, during, and after a scientific expedition to Mera Peak (5,800 m). The n-butanol test was used for the assessment of the magnitude of the
Anti-hypoxic activity at simulated high altitude was isolated in petroleum ether extract of Saussurea involucrata.
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BACKGROUND
Rhodiola algida, Saussurea involucrata, and other herbs grown in Qinghai-Tibetan plateau have long been used to prevent and treat acute mountain sickness.
OBJECTIVE
To screen and identify the anti-hypoxic constituents in the herbs grown in Qinghai-Tibetan plateau of Northwestern
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