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nephrocalcinosis/hypoxia
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Medullary nephrocalcinosis, distal renal tubular acidosis and polycythaemia in a patient with nephrotic syndrome.
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BACKGROUND
Medullary nephrocalcinosis and distal renal tubular acidosis are closely associated and each can lead to the other. These clinical entities are rare in patients with nephrotic syndrome and polycythaemia is an unusual finding in such patients. We describe the presence of medullary
Is there a role for uric acid in an animal model of calcium phosphate nephrocalcinosis and calcium phosphate crystallization in urine of patients with idiopathic calcium urolithiasis? An orientational study.
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Uric acid (UA), a waste product of purine metabolism, may be involved in calcium phosphate crystallization and deposition. Rats, which develop nephrocalcinosis on high-fat or magnesium-deficient diets, and patients with idiopathic calcium urolithiasis have hyperproteinuria, especially of nonalbumin
Nephrocalcinosis.
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The pathogenesis of NC in VLBW infants appears to be multifactorial. The vulnerability of extreme immaturity and the underdevelopment of renal function may be the most important variables. In some ways, we view this problem as similar to that of retinopathy of prematurity. (Clearly the exposure of
Hypercalcemic nephropathy: chronic disease with predominant medullary inner stripe injury.
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Because of the recently observed augmentation of medullary hypoxic injury by calcium in isolated perfused rat kidneys (Kidney Int 34:186-194, 1988), renal morphology of chronic, prolonged hypercalcemia was investigated in vivo. Rats were treated with repeated injections of vitamin D2 (400,000
Intrarenal distribution of exchangeable calcium in HgCl2-induced acute tubular necrosis.
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We used autoradiography to localize 45Ca accumulated in vitro by rat kidney that had been injured by HgCl2 in vivo. HgCl2, 1 mg/kg, was administered IV to male Sprague-Dawley rats and nephrectomies were performed from 15 min-30 days later. Kidney slices were incubated in KRB buffer containing 2 mM
Subcutaneous Fat Necrosis of the Newborn: A 20-Year Retrospective Study.
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Subcutaneous fat necrosis of the newborn (SFN) is a rare form of panniculitis that can be complicated by hypercalcemia and nephrocalcinosis. We conducted a 20-year retrospective cohort study of 30 patients to describe the clinical characteristics of SFN and the prevalence of hypercalcemia and other
Medical complications in long-term survivors with X-linked myotubular myopathy.
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OBJECTIVE
X-linked myotubular myopathy (MTM1) is a rare developmental disorder of skeletal muscle characterized by the presence of central nuclei in biopsy specimens from affected male subjects. Until recently, the disorder was usually fatal within the first year of life. This study was undertaken
The diagnostic role of urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in the detection of renal tubular impairment.
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The kidney function can be assessed by a number of methods. The urinary excretion of enzymes, in particular N-acetyl-beta-D-glucosaminidase (NAG), is considered a relatively simple, cheap, fast and non-invasive method in the detection and follow-up of renal tubular function under various conditions.
Clinicopathological variables predicting progression of azotemia in cats with chronic kidney disease.
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BACKGROUND
Chronic kidney disease (CKD) is common in geriatric cats, but often appears to be stable for long periods of time.
OBJECTIVE
To describe CKD progression and identify risk factors for progression in newly diagnosed azotemic cats.
METHODS
A total of 213 cats with CKD (plasma creatinine
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