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neurogenic inflammation/cefalea
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Therapeutic agents for the treatment of migraine
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FIELD OF THE INVENTION
The present invention relates to novel small molecule antagonists of calcitonin gene-related peptide receptors ("CGRP-receptor"), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment
Substituted imidazo[1,5-a]pyrazines as CGRP receptor antagonists
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BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
CGRP receptor antagonist
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BACKGROUND OF THE INVENTION
The disclosure generally relates to the compound (R)--N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperaz- in-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-- carboxamide (Compound I or the compound of formula I), including
Modulation of substance P by compounds containing calcium sulfate and methods relating thereto
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TECHNICAL FIELD
The present invention relates generally to a method of modulating substance P by compounds containing calcium sulfate, particularly syngenite, gorgeyite and gypsum, and more specifically, to the synthesis of such compounds as well as their use to treat a variety of conditions
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
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FIELD OF THE DISCLOSURE
The present disclosure relates to nutritional supplements. Specifically, the present disclosure relates to nutritional supplements used to treat and/or prevent inflammation and disease states and conditions resulting from inflammation.
BACKGROUND
The human diet has been known
CGRP receptor antagonists
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BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
CGRP receptor antagonists
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BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
CGRP receptor antagonists
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BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
CGRP receptor antagonists
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BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
Constrained compounds as CGRP-receptor antagonists
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BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Constrained compounds as CGRP-receptor antagonists
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BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Constrained compounds as CGRP-receptor antagonists
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BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Constrained compounds as CGRP-receptor antagonists
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BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Constrained compounds as CGRP-receptor antagonists
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BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Calcitonin gene related peptide receptor antagonists
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FIELD OF THE INVENTION
The present invention relates to novel small molecule antagonists of calcitonin gene-related peptide receptors ("CGRP-receptor"), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment
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