Active bilateral ultrasound-guided transmuscular quadratus lumborum (TQL) block. 60 mL ropivacaine 0.375% single shot.
In both arms morphine will be administered IV as part of a patient controlled analgesia PCA)-pump regimen or additionally after contact with the nursing staff as it is the standard treatment.

Placebo bilateral ultrasound-guided transmuscular quadratus lumborum (TQL) block. 60 mL Saline single shot.
In both arms morphine will be administered IV as part of a patient controlled analgesia PCA)-pump regimen or additionally after contact with the nursing staff as it is the standard treatment.

Postoperative Pain

Ropivacaine

Saline

Zealand University Hospital, Department of Anaesthesiology

Transmuscular Quadratus Lumborum Block for Total Laparoscopic Hysterectomy.

Ultrasound-guided Transmuscular Quadratus Lumborum Block for Laparoscopic Hysterectomy. A Double Blind, Randomized, Placebo Controlled Trial.

How much cumulated opioid in oral morphine equivalents does the participant require/use.

Zealand University Hospital

Active bilateral ultrasound-guided transmuscular quadratus lumborum (TQL) block. 60 ml ropivacaine 0,375% single shot.
In both arms, the participants receive 1g Acetaminophen and 400 mg Ibuprofen / 100 mg Celebra. Morphine will be administered IV as part of a PCA-pump regimen or additionally after contact with the nursing staff as it is the standard treatment.

Placebo bilateral ultrasound-guided transmuscular quadratus lumborum (TQL) block. 60 ml saline single shot.
In both arms, the participants receive 1g Acetaminophen and 400 mg Ibuprofen / 100 mg Celebra. Morphine will be administered IV as part of a PCA-pump regimen or additionally after contact with the nursing staff as it is the standard treatment.

Only women scheduled for elective caesarean section are eligible.

30 ml ropivacaine 0,375% administered on each side as bilateral TQL blocks

30 ml saline 0,375% administered on each side as bilateral TQL blocks

Acetaminophen

Ibuprofen 400Mg Tablet / Celebra 100 Mg tablet

Transmuscular quadratus lumborum block, ultrasound-guided

ultrasound-guided nerve block

intravenously administered morphine via PCA-pump

Morphine

PCA-pump with IV-Morphine. 5 mg administered per bolus. Lock-out time and max. dosage standardized.

Patient-controlled analgesia

Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section.

Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section. A Double Blind, Randomized, Placebo Controlled Trial.

Data from PCA pump and patient medical record

NRS score will be recorded electronically on all morphine administrations, since all patients must enter their NRS score on the PCA pump display prior to administration of the PCA boluses.

0=Complete satisfaction 10=Unmanageable dissatisfaction

PONV. 0-3; 0=No nausea. 3=Unmanageable nausea

When does the new mother ambulate. I.e. Unassisted visit at the bathroom.

W&D should begin when participants wish to conceive. The intervention was standardized by training of research staff. Careful instructions about walking speed and diet would be given to participants assigned to W&D at enrolment and at each consultation.

No recommendations regarding diet or physical activity were given to controls. Antiemetics such as ondansetron would be given to controls complaining of vomiting.

The intervention was standardized by training of research staff and should begin when participants wish to conceive. Careful instructions about walking speed and diet would be given to participants assigned to W&D at enrolment and at each consultation.
Walking & dietary modification: 1. Daily walking at a moderate pace (4 km/h) > 40 min, 7/7. Those whose jobs required them to seat for long periods should walk 25-30 min twice a day, avoiding >12 h of physical inactivity. Walking may be replaced by stationary bicycle rides or swimming when convenient, such as near term.
2. At least two daily servings of protein-rich food (≥ 4 g/kg of meat, poultry, fish or eggs) per day. Avoidance of high-carbohydrate, low-fiber meals, such as snacks, candies, fiber-free juices, coconut water or sugar-sweetened beverages. Sucralose could be used as a sweetener. Participants were recommended to use ondansetron for nausea and vomiting prevention

Walking & Dietary Modification (W&D)

Controls

Total

Sex: Female, Male

Race (NIH/OMB)

Region of Enrollment

Normal or underweight (BMI <25 kg/m2)

Owerweight (BMI 25–30 kg/m2)

Obese (BMI > 30 kg/m2)

Type 1 diabetes mellitus

Chronic hypertension

Women with live offspring

The intervention was standardized by training of research staff and should begin when participants wish to conceive. Careful instructions about walking speed and diet would be given to participants assigned to W&D at enrollment and at each consultation.
Walking & dietary modification: 1. Daily walking at a moderate pace (4 km/h) > 40 min, 7/7. Those whose jobs required them to seat for long periods should walk 25-30 min twice a day, avoiding >12 h of physical inactivity. Walking may be replaced by stationary bicycle rides or swimming when convenient, such as near term.
2. At least two daily servings of protein-rich food (≥ 4 g/kg of meat, poultry, fish or eggs) per day. Avoidance of high-carbohydrate, low-fiber meals, such as snacks, candies, fiber-free juices, coconut water, sugar-sweetened beverages and large amount of fruits. Sucralose could be used as a sweetener. Participants were recommended to use ondansetron for nausea and vomiting prevention

Take-home Baby Rate

The intervention was standardized by training of research staff and should begin when participants wish to conceive. Careful instructions about walking speed and diet would be given to participants assigned to W&D at enrollment and at each consultation.
Walking & dietary modification: 1. Daily walking at a moderate pace (4 km/h) > 40 min, 7/7. Those whose jobs required them to seat for long periods should walk 25-30 min twice a day, avoiding >12 h of physical inactivity. Walking may be replaced by stationary bicycle rides or swimming when convenient, such as near term.
2. At least two daily servings of protein-rich food (≥ 4 g/kg of meat, poultry, fish or eggs) per day. Avoidance of high-carbohydrate, low-fiber meals, such as snacks, candies, fiber-free juices, coconut water, sugar-sweetened beverages or large amount of fruits. Sucralose could be used as a sweetener. Participants were recommended to use ondansetron for nausea and vomiting prevention

Gestational Diabetes Mellitus

Preeclampsia

Mothers Who Used Heparin for Nephrotic Range Proteinuria or Placental Insufficiency

Weight gain >13 kg for underweight, normal weight or overweight mothers and > 9 kg for obese mothers

Excessive Weight Gain

First-trimester Losses

Second and Third-trimester Losses

Live-born Children

Babies Born at Term

Appropriate-for-gestational Age Babies

Hypoglycemia was defined as any blood glucose concentration ≤ 40 mg/dL.

Neonates With Hypoglycemia

Overall Study

Dr. Silvia Hoirisch-Clapauch

The intervention was standardized by training of research staff and should begin when participants wish to conceive. Careful instructions about walking speed and diet will be given to participants assigned to W&D at enrollment and at each consultation.
Walking & dietary modification: 1. Daily walking at a moderate pace (4 km/h) > 40 min, 7/7. Those whose jobs required them to seat for long periods should walk 25-30 min twice a day, avoiding >12 h of physical inactivity. Walking may be replaced by stationary bicycle rides or swimming when convenient, such as near term.
2. At least two daily servings of protein-rich food (≥ 4 g/kg of meat, poultry, fish or eggs) per day. Avoidance of high-carbohydrate, low-fiber meals, such as snacks, candies, fiber-free juices, coconut water, sugar-sweetened beverages or large amount of fruits. Sucralose could be used as a sweetener. Participants were recommended to use ondansetron for nausea and vomiting prevention

Recurrent Miscarriage

Daily walking at a moderate pace (4 km/h) > 40 min, 7/7. Those remaining seated most of the day should walk 25-30 min twice a day, avoiding >12 h of physical inactivity. Walking may be replaced by stationary bicycle rides or swimming when convenient, which often occurred near term and when the mother was obese.
At least two daily servings of protein-rich food (≥ 4 g/kg of meat, poultry, fish or eggs) per day. Avoidance of high-carbohydrate, low-fiber meals, such as snacks, candies, fiber-free juices, coconut water or sugar-sweetened beverages. Sucralose could be used as a sweetener. Participants are recommended to use ondansetron for nausea and vomiting prevention

Walking & dietary modification

Hospital Federal dos Servidores do Estado, Ministry of Health

Walking and Dietary Modification for Recurrent Early Miscarriages

Walking and Dietary Modification for Women With Consecutive Early Miscarriages: a Randomized Study

Silvia Hoirisch Clapauch

Principal Investigator

Hospital dos Servidores do Estado do Rio de Janeiro

Participants were not blinded, but visits of the two groups were scheduled so as to not coincide..

paraplegia/náusea

Transmuscular Quadratus Lumborum Block for Total Laparoscopic Hysterectomy.

Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section.

Walking and Dietary Modification for Recurrent Early Miscarriages

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