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Página 1 desde 38 resultados
Pharmaceutical composition for prevention and treatment of diabetes or obesity comprising a compound that inhibits activity of dipeptidyl peptidase-IV, and other antidiabetic or antiobesity agents as active ingredients
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a 371 of PCT/KR2009/005970 filed on Oct. 16, 2009, which claims the benefit of Korean Patent Application No. 10-2008-0101932 filed on Oct. 17, 2008, the contents of each of which are incorporated herein by reference.
TECHNICAL FIELD
The
Peptide-peptidase inhibitor conjugates and methods of using same
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TECHNICAL FIELD
The present disclosure relates to peptide molecules and, more particularly, to peptide-peptidase inhibitor conjugate molecules. The disclosure also relates to the medical field, in particular to the fields of metabolic and cardiovascular diseases.
BACKGROUND
Many peptides and peptide
Peptide-peptidase-inhibitor conjugates and methods of making and using same
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BACKGROUND
Many peptides and peptide hormones are involved in the body's regulation of a normal, healthy metabolic state. Central to many metabolic diseases and disorders is the regulation of insulin levels and blood glucose levels. A number of hormones that lower blood glucose levels are released
Heterocyclic compounds as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
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FIELD OF THE INVENTION
The present invention relates to substituted six-membered heterocyclic compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-4 inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is
Combined use of dipeptidyl peptidase 4 inhibitor and sweetener
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TECHNICAL FIELD
The present invention relates to a method for reducing body weight, reducing body fat mass and/or treating or preventing obesity, a pharmaceutical composition for the same, and use thereof.
More specifically, the present invention relates to a method for reducing body weight,
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
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FIELD OF THE INVENTION
The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
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FIELD OF THE INVENTION
The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, various
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
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FIELD OF THE INVENTION
The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DDP-IV)
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FIELD OF THE INVENTION
The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
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FIELD OF THE INVENTION
The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, cardiovascular diseases
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
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FIELD OF THE INVENTION
The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
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FIELD OF THE INVENTION
The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
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FIELD OF THE INVENTION
The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, .beta.-cell failure, obesity, satiety
Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
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FIELD OF THE INVENTION
The present invention relates to a particular salt of a dipeptidyl peptidase-IV inhibitor. More particularly, the invention relates to a dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8-
Use of N-(substituted glycyl)-2-cyanopyrrolidines in inhibiting dipeptidyl peptidase-IV
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FIELD OF THE INVENTION
The present invention relates to the area of dipeptidyl peptidase-IV (DPP-IV) inhibition. DPP-IV is a serine protease which cleaves N-terminal dipeptides from a peptide chain containing, preferably, a proline residue in the penultimate position. Although the biological role of
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