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Página 1 desde 43 resultados
Quinone compounds and their uses for the treatment of cancer
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This application is related to United Kingdom patent application GB 1213486.2 filed 30 Jul. 2012, the contents of which are incorporated herein by reference in their entirety.
FIELD OF THE INVENTION
The present invention relates to quinone compounds and their medical uses, in particular for the
Aziridinyl quinone anti-transplanted tumor agents
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BACKGROUND AND SUMMARY OF THE INVENTION
The present invention relates to the use of aziridinyl quinones as potential central nervous system antitumor agents. More particularly, the present invention is concerned with a diaziridinyldi(carboethoxyamino)benzoquinone which has been found to have
Ortho-quinone derivatives novel synthesis therefor and their use in the inhibition of neoplastic cell growth
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FIELD OF THE INVENTION
This invention is directed to novel o-quinone and o-naphthoquinone derivatives which are structurally related to naturally-occurring lapachones and dunniones. The present invention is also drawn to a novel synthetic method to produce tricyclic derivatives, including lapachone
Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
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STATEMENT OF RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH
Not applicable
TECHNICAL FIELD
This invention relates to therapeutic compositions in which a cytostatic or cytocidal compound, such as a polyamine analog or a quinone, is conjugated to a polypeptide recognized and cleaved by
Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
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STATEMENT OF RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH
Not applicable
TECHNICAL FIELD
This invention relates to therapeutic compositions in which a cytostatic or cytocidal compound, such as a polyamine analog or a quinone, is conjugated to a polypeptide recognized and cleaved by
Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth
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FIELD OF THE INVENTION
This invention is directed to novel o-quinone and o-naphthoquinone derivatives which are structurally related to naturally-occurring lapachones and dunniones. The present invention is also drawn to a novel synthetic method to produce tricyclic derivatives, including lapachone
Pharmaceutical compositions of .beta.-lapachone and .beta.-lapachone analogs with improved tumor targeting potential
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FIELD OF THE INVENTION
The present invention relates to improved compositions and methods for delivering therapeutic agents bearing carbonyl or quinone functionalities and improved methods for treating cancer. One embodiment of the invention relates to improved .beta.-lapachone compositions and
Method for treating hematopoietic neoplasms
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II. INTRODUCTION
Cancer is a leading cause of death in the industrialized world and despite years of research, many types of cancer lack an effective therapeutic treatment. Although chemotherapy induces remission in the majority of adult patients with acute myeloid leukemia (AML), only a small
Quinones as disease therapies
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STATEMENT OF RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH
Not applicable.
TECHNICAL FIELD
This invention relates to novel quinones. The invention also relates to conjugates of quinones with various peptides. The invention also relates to various medicinal and industrial uses of these
Quinones as disease therapies
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TECHNICAL FIELD
This invention relates to novel quinones. The invention also relates to conjugates of quinones with various peptides. The invention also relates to various medicinal and industrial uses of these compounds, including the use of these compounds in treating diseases such as
Quinones as disease therapies
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STATEMENT OF RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH
Not applicable.
TECHNICAL FIELD
This invention relates to novel quinones. The invention also relates to conjugates of quinones with various peptides. The invention also relates to various medicinal and industrial uses of these
Method and composition for treating cancer
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This invention relates to new analogues of actinomycin D and to a method of preparing them.
Actinomycin D (AMD) is disclosed in German Pat. No. 1,172,680 and is a chromopeptide antibiotic whose potent activity in several tumors, including Wilm's tumor, gestational choriocarcinoma and Kaposi's
Ascorbate, vitamin K3 and hydroxytolans in the treatment of cancer
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FIELD OF THE INVENTION
The invention in the field of biochemistry and medicine relates to combination therapy of cancer using compounds of the hydroxytolan (HT) family in combination with ascorbate and naphthoquinone (Vitamin K.sub.3 or "VK.sub.3") or a quinone or semiquinone analogue of
Method for reducing tumors and transforming cancer cells
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TECHNICAL FIELD
The present invention relates to a cancer therapy, especially of the therapy using phenols and quinones to melt and transform cancer tumor.
BACKGROUND
Cancer cells are the result of structural changes in healthy nucleus. They are transformed from the body's own healthy cells under a
Phosphoaziridine compounds useful for treatment of tumors
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TECHNICAL FIELD
This invention relates to phosphoraziridine compositions and to their use as antineoplastic agents. The invention more particularly relates to novel phosphoraziridine compositions and their use in controlling leukemia and tumors. The compositions also find utility as antibacterials
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