400mg/daily of hydroxychloroquine for 8 weeks

Cardiovascular Diseases

Endothelial Dysfunction

Sleep Apnea

Atherosclerosis

Coronary Artery Disease

Hydroxychloroquine

Placebo oral tablet

Hospital de Clinicas de Porto Alegre

Anti-Inflammatory Drug and Endothelial Function

Effect of Hydroxychloroquine on Endothelial Function: a Clinical Trial

The reactive-hyperemia index (RHI) scale ranges from -0.4 to 1.6. Below -0.51 being endothelial dysfunction, a higher score indicates a better endothelial function

The FMD-response will be calculated as the variation in post-hyperaemia brachial artery diameter from baseline, measured in relative (percentage) change. A mean improvement in flow mediated dilatation of at least 2% would usually be required to detect a treatment benefit.

Determined by total cholesterol, HDL-cholesterol and triglycerides blood levels (mg/dL)

The risk of developing cardiovascular disease is quantified as follows:
low: CRP level under 1.0 mg/L average: between 1.0 and 3.0 mg/L high: above 3.0 mg/L

calculated by dividing the number of neutrophils by number of lymphocytes. The mean range of healthy adult subjects is between 0.78 and 3.53.

The data will be collected through the system of acquisition of pressure waves in a continuous and non-invasive way by the Finometer® system, through a cuffing installed in the middle finger, taking this signal to an analog-to-digital signal converter. The pulse pressure signal will be acquired at 1000 Hz, continuously and non-invasively, supine (10 minutes) in a quiet environment, with controlled temperature (± 23 ° C) and illumination. The collected data will be saved in the software BeatsScope® and LabChart®, from which will be extracted the systograms for analysis.

Apnea/Hypopnea index is provided by home respiratory polygraphy, ranging from 0-highest events/hour, zero-5 eventos/hour being normal and above 5 events/hour being abnormal

Instituto de Cardiologia do Rio Grande do Sul

34 osteopenic postmenopausal women with chronic periodontitis who received calcium (500mg) and vitamin D (250I.U.) supplementation twice a day for 6 months.Scaling and root planing was not done in this group.

34 osteopenic postmenopausal women with chronic periodontitis who received scaling and root planing along with calcium (500mg) and vitamin D (250I.U.) supplementation twice a day for 6 months.

PERIODONTITIS

Osteopenia

calcium (500mg) and vitamin D (250I.U.) was given twice a day for 6 months

calcium (500mg) and vitamin D (250I.U.)

scaling and root planing was done in the test group along with calcium (500mg) and vitamin D (250I.U.)

Scaling and root planing

Effect of Periodontitis on Bone Mineral Density in Postmenopausal Women

Postgraduate Institute of Dental Sciences Rohtak

Between tumor biopsy and surgery, during 2-3 weeks, breast cancer patients will take daily HCQ, an anti-malaria and anti-rheumatic drug that precludes tumor cells from surviving hypoxia by inhibiting the process of autophagy in these cells

Breast Cancer

800 mg per os once, and then 400 mg per day

Hydrochloroquine

University Medical Centre Nijmegen

Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients

Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients:a Pilot Study

differences in endogenous hypoxia markers (CA9, PAI-1, VEGF [Rademakers et al. 2008]) and autophagy (LC3b [Rouschop et al. 2010]) before and after treatment with HCQ. These parameters will be quantified by immunohistochemistry on formalin fixed paraffin embedded tissue from both pretreatment biopsy, and posttreatment surgically obtained material.

differences in putative crucial mediators in the autophagy pathway currently under investigation, i.e. TRB3, ATF4, GRP78, LAMP3, etc.before and after short-term pre-surgical treatment with HCQ

rheumatic diseases/hypoxia

Anti-Inflammatory Drug and Endothelial Function

Effect of Periodontitis on Bone Mineral Density in Postmenopausal Women

Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients

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