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Beethoven's renal disease based on his autopsy: a case of papillary necrosis.
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The autopsy report of Ludwig van Beethoven written by Dr Johann Wagner in 1827 reveals that he had renal calculi that had not been diagnosed during his lifetime, together with perirenal fibrosis. The most comprehensive interpretation of this autopsy finding is that the regular calcareous deposits in
Vascular protection of salicin on IL-1β-induced endothelial inflammatory response and damages in retinal endothelial cells.
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Retinal endothelial cells (RECs) are involved in many ocular diseases such as age-related macular degeneration (AMD) and diabetic retinopathy. Salicin is the major ingredient of willow bark extract, and it has been shown to be a potent anti-inflammatory agent. We aim to explore whether salicin has a
Salicin inhibits AGE-induced degradation of type II collagen and aggrecan in human SW1353 chondrocytes: therapeutic potential in osteoarthritis.
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Osteoarthritis (OA) is a major age-related disease, which may be caused by the accumulation of advanced glycation end-products (AGEs). Excessive degradation of type II collagen and aggrecan by matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin type 1 motif
Atypical Pasteurella haemolytica type A from poultry.
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Atypical strains of Pasteurella haemolytica that failed to ferment maltose were isolated from nodular necrosis in the liver and heart blood of domestic fowl (Gallus domestica). These strains did not typically behave like either of the two well-known biotypes of P. haemolytica. The strains utilized
STUDIES IN BOVINE MASTITIS : I. NON-HEMOLYTIC STREPTOCOCCI IN INFLAMMATION OF THE UDDER.
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It seems clearly established that non-hemolytic streptococci are responsible for a considerable number of cases of bovine mastitis. Of the 81 animals examined, 31 were suffering from infections of this type. The lesions produced in invaded quarters varied from an involvement of only the lining
Effects of an ethanolic salix extract on the release of selected inflammatory mediators in vitro.
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Salix extracts are in current use for the treatment of pain and inflammation. In order to obtain an insight into the mechanism(s) of action of the ethanolic Salix extract 1520L--which is essentially similar to an extract for which clinical studies have demonstrated analgesic effectiveness--its
Anti-inflammatory effects of the willow bark extract STW 33-I (Proaktiv(®)) in LPS-activated human monocytes and differentiated macrophages.
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BACKGROUND
Willow bark extract is frequently used in the treatment of painful rheumatological diseases, such as arthritis and back pain. Its effect has been attributed to its main component salicin, but pharmacological studies have shown that the clinical efficacy of the willow bark extract cannot
Efficacy and Safety of White Willow Bark (Salix alba) Extracts.
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Willow bark extract has been used for thousands of years as an anti-inflammatory, antipyretic, and analgesic. In spite of its long history of use, relatively few human and animal studies have been published that confirm anecdotal observations. A small number of clinical studies have been conducted
Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE(2), and TNF-alpha production.
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Three new phenolic glycosides, salviifosides A-C (13), and three known compounds salicin (4), kaempferol (5), and kaempferol 3-O-beta-d-glucopyranoside (6) were isolated from the leaves of Alangium salviifolium (L.f.) Wangerin (Alangiaceae). The structures of the new metabolites were determined on
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