sudden unexpected death in epilepsy/edema

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Dead in the water: Epilepsy-related drowning or sudden unexpected death in epilepsy?

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OBJECTIVE Both drowning and sudden unexpected death in epilepsy (SUDEP) are diagnoses of exclusion with predominantly nonspecific autopsy findings. We hypothesized that people with epilepsy found dead in water with no clear sign of submersion could be misdiagnosed as SUDEP. METHODS All reported

Pulmonary edema following generalized tonic clonic seizures is directly associated with seizure duration.

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OBJECTIVE Postictal pulmonary edema (PPE) is almost invariably present in human and animal cases of sudden unexpected death in epilepsy (SUDEP) coming to autopsy. PPE may be a contributing factor in SUDEP. The incidence of postictal PPE is unknown. We retrospectively investigated PPE following

Postictal neurogenic pulmonary edema: Case report and brief literature review.

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Cardiopulmonary complications associated with epilepsy are generally associated with generalized tonic-clonic seizures, as a consequence of systemic adrenergic discharge and release of inflammatory mediators. We present a case of a 34-year-old woman with a history of Focal epilepsy since

Pediatric Sudden Unexpected Death in Epilepsy: What Have we Learned from Animal and Human Studies, and Can we Prevent it?

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Several factors, such as epilepsy syndrome, poor compliance, and increased seizure frequency increase the risks of sudden unexpected death in epilepsy (SUDEP). Animal models have revealed that the mechanisms of SUDEP involve initially a primary event, often a seizure of sufficient type and severity,

Sudden Unexpected Death in Epilepsy: Incidence, Risk Factors, and Proposed Mechanisms.

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Epilepsy is a common neurological disorder associated with increased morbidity and mortality, including premature death from different causes. Sudden unexpected death in epilepsy, or SUDEP, is one of the most common causes of death in people with epilepsy and originally brought to light by medical

Respiratory pathophysiology with seizures and implications for sudden unexpected death in epilepsy.

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CONCLUSIONS There is increasing evidence that periictal respiratory disturbances are an important contributor to the pathophysiological changes leading to sudden unexpected death in epilepsy (SUDEP). In patients with SUDEP occurring in epilepsy monitoring units, respiratory disturbances occurred

Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms.

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Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death directly related to epilepsy, and most frequently occurs in people with chronic epilepsy. The main risk factors for SUDEP are associated with poorly controlled seizures, suggesting that most cases of SUDEP are

Highlights in clinical autonomic neurosciences: sudden unexpected death in epilepsy.

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Sudden unexplained death in epilepsy (SUDEP) is an important unresolved problem affecting many patients with recurrent seizures. Amongst the mechanisms postulated are ictal or postictal cardiac arrhythmias, central hypoventilation or apnea, and neurogenic pulmonary edema. Across these categories, a

Pulmonary and cardiac pathology in sudden unexpected death in epilepsy (SUDEP).

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To review studies on structural pulmonary and cardiac changes in SUDEP cases as well as studies showing pulmonary or cardiac structural changes in living epilepsy patients. We conducted electronic literature searches using the PubMed database for articles published in English, regardless of

A prospective study on sudden unexpected death in epilepsy.

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Sudden unexpected death accounts for a substantial portion of deaths among epileptics. The incidence of this phenomenon is probably 1 in 370 to 1 in 1,110 in the general epileptic population but may be even higher in the 20- to 40-year age group, and still higher if epileptics with symptomatic

Mortality in captive baboons with seizures: a new model for SUDEP?

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Because the baboon is a model of primary generalized epilepsy, we were interested in mortality of captive animals with a history of witnessed seizures. Causes of natural death were investigated in 46 seizure baboons (SZ) and 78 nonepileptic controls (CTL), all of which underwent a complete

Epileptic sudden death: animal models.

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The pathologic hallmark of sudden unexpected death in epilepsy (SUDEP) in humans is pulmonary edema. In an animal model of seizures, pulmonary vascular pressure, but not systemic pressure, increases in proportion to seizure duration. The induced pulmonary vascular hypertension drives fluid out of

Sudden unexpected death associated with HHV-6 in an adolescent with tuberous sclerosis.

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A 14-year-old female with tuberous sclerosis and history of seizures was found dead in bed at home 3 days after she had been assessed as doing well at a routine neurology clinic appointment. She had been treated with an antiepileptic drug, felbamate, for 36 months and had been seizure-free except

[Mortality in epilepsies].

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BACKGROUND The overall mortality associated with epilepsy has been estimated to be two or three times that of the general population. Data from contemporary studies show excess mortality in the first decade of life and the first few years after diagnosis. METHODS The underlying disease of which

Autonomic dysfunction may not be the only cause of SUDEP

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With interest we read the article by Vinholes et al. about assessment of the risk for sudden unexpected death in epilepsy (SUDEP) in 10 patients with frontal lobe epilepsy (FLE) by means of testing the autonomic innervation of the cardiac conduction system and the myocardium with spectral analysis

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