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trichinellosis/glutatión
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Trichinellosis in mice: effect of albendazole on the glutathione transferase in the intestines.
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The glutathione S-transferases (GSTs) are a family of multifunctional enzymes involved in cellular detoxification. The aim of this study was to evaluate the effect of albendazole--drug of choice for trichinellosis--on the total activity and kinetics of cytosolic GST in the mouse intestines during
Changes in the activity and kinetics of mouse intestinal glutathione transferase during experimental trichinellosis.
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The glutathione S-transferases (GSTs) are a group of multifunctional enzymes, which play a critical role in cellular detoxification. Our investigations deal with the contribution of GST in the biochemical defense against Trichinella spiralis infection. The aim of this study was to examine the effect
Glutathione-S-transferase activity in mouse muscle during experimental trichinellosis.
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The role of glutathione-S-transferase (GST, EC 2.5.1.18) in biochemical host defence in experimental trichinellosis was evaluated. The activity of GST in mouse skeletal muscles was measured during the muscular phase of trichinellosis, starting from the 3rd week post infection (w.p.i.) to the 11th
Evaluation of effects of albendazole on the kinetics of cytosolic glutathione transferase in skeletal muscles during experimental trichinellosis in mice.
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In this study, the effect of trichinellosis as well as the effect of albendazole treatment on the kinetics of substrate saturation of cytosolic glutathione transferase (GST) in the skeletal muscles from infected mice was examined because the idea of multifunctional mode of action of anthelmintic
Glutathione-S-transferase omega 1 and nurse cell formation during experimental Trichinella infection.
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The glutathione-S-transferases omega (GSTO) are multifunctional enzymes involved in cellular defense. During the nurse cell (NC) formation in Trichinella spiralis infection, the structural and regulatory genes of the skeletal muscle cell are downregulated and a new phenotype is acquired which
[Effect in vitro of albendazole on the kinetics of cytosolic glutathione transferase from the rat liver].
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BACKGROUND
Since the idea of multifunctional mode of action of anthelmintics is considered and in experimental trichinellosis in vivo albendazole seems to act as an allosteric activator of cytosolic GST from mice muscles, in this study a termosensitivity after in vitro incubation with albendazole of
[The intriguing influence of albendazole on glutathione reductase activity in the muscles from Trichinella spiralis infected mice].
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A clear stimulation of the activity of glutathione reductase (RG, EC 1.6.4.2), one of the major enzymes participating in glutathione metabolism, was observed in the skeletal muscles from Trichinella spiralis infected mice. The maximal, almost two-fold increase in RG activity was observed in week 5
Up-regulation of the 31 kDa dehydroascorbate reductase in the modified skeletal muscle cell (nurse cell) during Trichinella spp. infection.
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Ascorbic acid (AA) is an important factor of defence against oxidative stress. AA is maintained in the reduced functional form by glutathione (GSH)-dependent dehydroascorbate (DHA) reducing enzymes, including the cytosolic glutaredoxin, the microsomal protein disulphide isomerase, and a DHA
Changes in the level of antioxidants in the blood from mice infected with Trichinella spiralis.
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The biological reaction caused by oxygen-derived free radicals at the molecular and cellular levels involves many different biochemical components which can be directly damaged by oxidizing radicals. As such a reaction may lead to pathological processes, defence mechanisms have evolved to limit the
Selenium supplementation at low doses contributes to the antioxidant status in Trichinella spiralis-infected rats.
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Selenium (Se) supplementation may prevent the formation of free radicals and lipid peroxidation processes in trichinellosis. The oxidative-antioxidant status of male Wistar rats infected or uninfected with Trichinella spiralis (Nematoda) and supplemented or unsupplemented with Sel-plex (Alltech) was
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