2 sachets/day: 800 mg of α-Lipoic acid, 450 mg of magnesium bisglycinate, 300 mg of L-Tryptophan, 20 mcg of Vitamin D3, 2.4 mg of Vitamin B2, 25 mg of Niacin, 150 mg of Coenzyme Q10. Patients who receive Migratens food supplementation have to take 2 sachets / day for 12 weeks. The supplement will be prescribed as usual and the assumption of the same will be recorded by partecipants in the appropriate daily; if the subject does not continue the indication the data collected up to that moment will be considered.

2 sessions a week, for a total of 10 (5 weeks), performed by the same operator, repeatable if necessary, after a therapeutic interval of at least one month. Each session lasts about 20-30 minutes per patient. Tewa J Type sterile disposable needles, coated, with a Chinese-style copper wire handle, with a guide tube, of 22x13 mm (CJ 2213) and 30x25 mm (CJ 3025) will be used. Acupuncture will be carried out by same trained operator.

Fibromyalgia, Primary

Fibromyalgic Sindrome

female affected by fybromialgia age between 30-65 years old

Migratens

Fibromyalgia Different Approaches: Acupuncture vs Migratens

Observation of Patients Affected by Fibromyalgic Syndrome (FMS): Comparison of Different Therapeutic Approaches

to observe pain reduction in fibromyalgic patients treated with nutraceutic (Migratens®) - Groupo A, and with acupuncture - Group B, at the end of the study. visual analogue scale is anagogic scale that evaluate continuous aspect of the scale differentiates it from discrete scales such as the Likert scale, from 0 to 10.

- to observe pain reduction in fibromyalgic patients treated with nutraceutic (Migratens®) - Groupo A, and with acupuncture - Group B, at different follow up time visual analogue scale is anagogic scale that evaluate continuous aspect of the scale differentiates it from discrete scales such as the Likert scale, from 0 to 10.

to value general improvement of cenestesi between two groups. each of the 9 questiona of questionnaire present a score from 0 to 10 to evaluate haw fibromyalgia make activities difficult, zero score correspond to no difficult and 10 to always difficult.

to observe time of pain reduction or pain free after treatment end. visual analogue scale is anagogic scale that evaluate continuous aspect of the scale differentiates it from discrete scales such as the Likert scale, from 0 to 10.

to observe number and type of treatment adverse effect during study time

Vittorio Schweiger

PROFESSOR

Melatonin 10mg and placebo, once in the evening, for 6 weeks.

Amitriptyline 25mg and placebo, once in the evening, for 6 weeks.

Melatonin 10mg and Amitriptylin 25mg, once in the evening, for 6 weeks.

Fibromyalgia

Melatonin and Placebo

Amitriptyline and Placebo

Melatonin and Amitriptylin

Hospital de Clínicas de Porto Alegre

Immune-Pineal Axis Function in Fibromyalgia

Phase II Role of Immune-pineal Axis in Fibromyalgia: Noradrenergic Modulation and Chronotherapeutic Aspects

Pain Pressure Threshold by Fischer algometer on the tender points.

Hospital de Clinicas de Porto Alegre

Fibromyalgia Syndrome

Those in the active treatment group will receive doses of Paxil CR in the following manner: week 1: 12.5 mg per day, week 2: 25 mg per day, week 3: 37.5 mg per day, wk 4: 50 mg per day and week 5: 62.5 mg per day.

Paroxetine CR

Placebo

Duke University Medical Center

Thomas Jefferson University

Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome

Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome: A Randomized, Double Blind, Parallel Group, Flexible Dose, Placebo Controlled Trial.

tryptophan/cefalea

Fibromyalgia Different Approaches: Acupuncture vs Migratens

Immune-Pineal Axis Function in Fibromyalgia

Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome

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