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vulvar neoplasms/hypoxia
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Overexpression of carbonic anhydrase IX (CAIX) in vulvar cancer is associated with tumor progression and development of locoregional lymph node metastases.
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Carbonic anhydrase IX (CAIX) is a strictly membranous expressed metalloenzyme involved in cell adhesion, pH homeostasis, and cancer progression. The protein is specifically overexpressed in a wide variety of malignant tumors. This study was designed to assess the role of CAIX in primary vulvar
Hemoglobin level predicts outcome for vulvar cancer patients independent of GLUT-1 and CA-IX expression in tumor tissue.
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Intratumoral hypoxia has been associated with poor prognosis in several solid tumors. The aim of this study was to determine whether the hypoxia-associated markers glucose transporter (GLUT)-1 and carbonic anhydrase (CA)-IX expression and preoperative hemoglobin (Hb) levels correlate with presence
[A case of prolonged reduction in arterial oxygen saturation measured by pulse oxymetry after administering patent blue in an elderly patient].
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A 93-year-old woman with a vulvar cancer was scheduled for resection of the tumor and sentinel lymph node biopsy under general anesthesia. At the beginning of the operation, a total of 20 ml of 2.5% patent blue was injected into the tumor and the surroundings to identify sentinel lymph node. After
Oxygenation status of gynecologic tumors: what is the optimal hemoglobin level?
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BACKGROUND
Tumor hypoxia has been linked to the development of treatment resistance, tumor progression, and poor prognosis. Since anemia is a major causative factor for the development of hypoxia, the association between blood hemoglobin concentration (cHb) and tumor oxygenation was examined in this
Oxygenation status of primary and recurrent squamous cell carcinomas of the vulva.
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BACKGROUND
Cancers of the vulva are relatively rare and, therefore, little is known about the pathophysiological role of tumor oxygenation in this entity.
METHODS
Data are presented on the oxygenation status of primary (n = 15) and recurrent (n = 19) cancers of the vulva, as measured by the
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