[Age-related immunological characteristics in typhoid fever and their significance in the clinical manifestations of the disease].

The results of the comparison of the pattern of specific typhoid exanthema, as well as the time of its appearance, in elderly and senile patients and in young patients are presented; besides, some characteristics of humoral immunity in these groups of patients are compared. This comparison has revealed that in typhoid fever in elderly and senile patients roseola typhosa is more rare, while the phenomenon of eruption is more frequent than in young patients. The differences in the manifestation of exanthema, observed in patients of different age groups, are due to less intensive and regular antibody formation in elderly and senile patients, as well as to the decreased activity of their altered blood vessels of the skin.