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Journal of Dietary Supplements 2017-Jul

Biochemical and Histopathological Evidence on Beneficial Effects of Standardized Extract from Tragopogon graminifolius as a Dietary Supplement in Fatty Liver: Role of Oxidative Stress.

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Atena Sadeghi
Roodabeh Bahramsoltani
Roja Rahimi
Mohammad Hosein Farzaei
Fatemeh Farzaei
Zahra Minoosh Siavosh Haghighi
Mohammad Abdollahi

Märksõnad

Abstraktne

Nonalcoholic fatty liver disease (FLD) is a worldwide common liver disorder. Tragopogon graminifolius is used as a dietary supplement for liver disorders. This study aimed to assess the beneficial effects of a standardized preparation from T. graminifolius extract (TGE) in animal model of FLD induced by high-fat diet (HFD). The standardization of TGE based on phenolic compounds was performed using high-performance liquid chromatography (HPLC) analysis. The HFD induced metabolic and hepatic damages. TGE significantly reduced the elevations of serum triglyceride, cholesterol, low-density lipoprotein (LDL), and hepatic enzymes (p =.001 for 25, 50, and 100 mg/kg of TGE). Histopathological studies also confirmed beneficial effects of TGE in FLD. Activity of total antioxidant power, content of total thiol, myeloperoxidase (MPO) enzyme activity, and lipid peroxidation were significantly improved (p <.001). Dietary supplementation with TGE results in improvement of biochemical as well as histopathological parameters. Clinical trials are warranted to prove its efficacy and tolerability in patients with FLD.

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