Cluster analysis of the phenotype of asthma and obesity.

OBJECTIVE

Introduction: The combination of asthma and obesity can affect the mutual encumbrance to which other pathogenetic mechanisms join, which worsen the course of both diseases. The aim of the work is to analyze the features of the genotype and phenotype in patients with a combined course of asthma and obesity.

METHODS

Materials and methods: In order to detect the features of obesity asthma, 108 patients were examined. Patients were divided into two groups: the first included 50 patients with normal body weight, the second - 58 patients with obesity.

RESULTS

Results: The analysis of the history of the disease revealed that 98% of women with obesity with asthma started the illness at the mature age (50.9 years) against the background of age-related hormonal dysfunctions. Relatively rarely in the obesity group, allergic rhinitis and eosinophilia in the peripheral blood were diagnosed. In analyzing the indicators of the function of external respiration, it has been established that in obese patients, restrictive bronchoconstriction disturbances and more significant distal bronchial obstruction are more pronounced than in patients with normal body mass. In the group of obese patients, the majority were women, the disease was more often complicated by pulmonary insufficiency, emphysema of lungs, and co morbid condition - hypertension. In this group, the symptoms of asthma were constantly persistent, but worse controls.

CONCLUSIONS

Conclusions: The obtained data allow to distinguish the phenotype of patients with asthma with adjunctive obesity.