Growth plate uptake of Tc-99m-phytate on lymphoscintigraphy images.

We report two pediatric cases with the history of lower extremity edema who were referred to the nuclear medicine department for lower limb lymphoscintigraphy as lymphedema workup. Subcutaneous injection of Tc-99m phytate in the interdigital webs was used for both patients, followed by early and delayed whole body lymphoscintigraphy imaging. Images of both patients showed Tc-99m phytate accumulation in the growth plates of the lower limbs. This biodistribution could interfere with popliteal lymph node visualization and should always be taken into account in lymphoscintigraphy of pediatric patients. We also review the medical literature regarding biodistribution Tc-99m phytate after interstitial injections.