[The participation of histamine and serotonin in the genesis of acute kidney failure in patients with hemorrhagic fever with renal syndrome].

In order to explore possible involvement of histamine and serotonin in acute renal failure related to hemorrhagic fever with renal syndrome (HFRS), selected markers or renal lesions have been compared with biochemical findings in highly severe cases. Literature reports and the study results lead the authors to conclude that histamine and serotonin are obviously pathogenetic determinants of HFRS since their concentrations in plasma of these patients are increased 3-fold. It is suggested that the biologically active substances may be a link between renal disease and hyperergy in severe and critical disease forms.