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angiotensin/hypoxia

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Leht 1 alates 29 tulemused

Use of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Caused by COVID-19

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A Study of Mesenchymal Stem Cells as a treatment in Patients with Acute Respiratory Distress Syndrome caused by COVID-19 is a pilot phase, open label, non-randomized study, with a single study center. The current pandemic caused by the novel virus SARS-CoV-2 has lead to a health care crisis

PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort

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INTRODUCTION 1.1 BACKGROUND Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is a new rapidly spreading infectious disease with no proven treatment options. The virus causes a spectrum of disease ranging from mild coryzal symptoms to severe respiratory compromise requiring

Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome.

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Design: Randomized, parallel group, non-blinded, controlled clinical trial compared with conventional treatment. A. Protocol and intervention Patients with an AHI>30 h-1 will be assigned, using a 1:1 randomization table, to lifestyle recommendations treatment or to lifestyle recommendations plus

Predictors of Cardiovascular Risk in Covid-19 Patients During Acute Disease and at Short Term Follow-up

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Background COVID-19 has shown a lower case-fatality rate compared to other major viral outbreaks in contemporary history, including severe acute respiratory syndrome (SARS) of 2002-2003. However, the relative susceptibility to symptomatic infection and the case fatality risk increase substantially

COVID-19 Patient Positioning Pragmatic Trial

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Disease Progression and Timing of Intervention The intervention described herein focuses on adjustment of patient positioning aimed at improving gas exchange and lung function in patients harboring COVID-19. This intervention will target the inpatient setting generally. Scientific/Clinical Rationale
This is an investigator initiated, open label, multicenter, two arm, randomized study to compare the impact of adding an ARB to the Standard of Care (SOC) to the SOC without an ARB. Randomization ratio will be 1:1. The goal of this study is to identify whether or not ARBs have an impact on

Improving 24-hour Blood Pressure in Obstructive Sleep Apnea

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OSA is a sleep disorder characterized by repetitive collapses (apneas) or partial collapses (hypopneas) of the upper airway. These airway obstructions result in intermittent reductions in arterial oxygen saturation (hypoxia), which causes a reflexive increase in sympathetic activation and systemic

The Association Between Sleep Duration and Sleep Disorders and Proteinuria in Children

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200 children aged 2-18 years that will be referred to the Sleep Disorders Center for overnight polysomnography due to suspected sleep disordered breathing or PLMD will be recruited to the study during their first visit in the sleep clinic. During that study, an informed consent will be completed by

Evaluation of Coffee Therapy for Improvement of Renal Oxygenation

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Preventing Acute Kidney Injury (AKI) in Neonates

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Cardiac palliative/ correction surgeries in the newborns, infants, and children involve significant morbidity and mortality risks. Kidney function is frequently affected from cardiothoracic surgery in these children. Studies identify the incidence of acute kidney injury (AKI) to be approximately 54%

Perfusion Assessment With Contrast-Enhanced EUS in Locally Advanced and Metastatic Pancreatic Cancer

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Introduction and rationale: Pancreatic cancer (PC) is one of the most lethal and therapeutically resistant malignancies, with a grim prognosis that is attributed to the late clinical presentation and the relative chemoresistance of the disease. Even with identical chemotherapy regimens, some

Renal Artery Dopplers in Twin Twin Transfusion Syndrome

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TTTS, which complicates 10-15% of MCDA twin pregnancies, is characterized by a net imbalance of volume between twins, mediated through abnormal placental blood vessel anastomoses that connect the two placental circulations. Clinically, the "donor" twin develops features of anemia and hypovolemia,

sFlt-1:PlGF Ratio in Diagnosing Superimposed Preeclampsia

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Logi sisse
Subjects with a diagnosis of chronic hypertension made prenatally or in the first 20 weeks of pregnancy (+/- medical therapy). The clinical diagnosis of preeclampsia will follow the current criteria outlined by ACOG (American College of Obstetricians & Gynecologists) 10. Study/Project Procedures: -

AT1R Blockade and Periodic Breathing During Sleep in Hypoxia

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Logi sisse
Objective: To determine the effects of angiotensin-II, type-I receptor (AT1R) blockade on the relationship between ventilatory control and sleep disordered breathing (SDB) following a night of hypoxic sleep in healthy humans. Justification: Ventilatory adaptation to hypoxia is one of two major

Noninvasive Measurements of Renal Perfusion During Cardiac Surgery

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Acute kidney injury (AKI) is an unfortunately common complication of cardiac surgery that occurs in up to 40% of patients and results in increased mortality, prolonged ICU and hospital length of stay. AKI after cardiac surgery is not a benign complication, increasing mortality from 1% to 19% in
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