Experimental group: anlotinib(d1-14, d22-36), followed by 21 days period, 2 weeks medication, 1 week maintenance therapy.
. Group II: 10 mg po qd, Group III: 12 mg po qd;
Combined chemotherapy:
Cisplatin + etoposide Or PC: carboplatin AUC2, paclitaxel 45-50 mg 2 per week; Cisplatin + cultured beauty (non squamous cell carcinoma). Synchrotron radiation: radiotherapy combined with radiotherapy (3D-CRT or IMRT) (60-66Gy / day).
The curative effect was evaluated after 6 weeks of simultaneous radiotherapy and chemotherapy combined with alotinib, and then the efficacy of alotinib or chemotherapy was maintained until PD.

Patients With Non-small Cell Lung Cancer

Simultaneous chemoradiotherapy for An Luo

The second affiliated Hospital of Xi'an Jiaotong University

Study of Anlotinib Plus Chemoradiotherapy in Patients With Locally Advanced NSCLC

Phase I / II Clinical Study on the Safety and Preliminary Efficacy of Anlotinib Hydrochloride Combined With Platinum-containing Simultaneous Radiotherapy in the Treatment of Locally Advanced Non-small Cell Lung Cancer

complete response(CR)+partial response(PR) according to RECIST 1.1

overall survival is defined as the time from randomization to death from any cause

progression-free survival is defined as the time from enrollment to the date of first document disease progression or death from any cause

Second Affiliated Hospital of Xi'an Jiaotong University

Tang-Du Hospital

Xijing Hospital

First Affiliated Hospital Xi'an Jiaotong University

Shaanxi Provincial Cancer Hospital

Shaanxi Provincial People's Hospital

Experimental group: anlotinib (D1-14, d22-36, followed by 21 days cycle, taking medicine for 2 weeks, stopping for 1 week).
Group 1: 8mg po qd, Group 2: 10mg po qd, Group 3: 12mg po qd;
Combined chemotherapy:
Cisplatin + etoposide or PC: carboplatin AUC2, paclitaxel 45-50 mg 2 per week; Cisplatin + pemetrexed (non-squamous cell carcinoma). Simultaneous radiotherapy: 3D-CRT or IMRT external radiotherapy (60-66 Gy, 2.0 Gy / day).
The curative effect was evaluated after 6 weeks of simultaneous radiotherapy and chemotherapy combined with alotinib, and then the efficacy of alotinib or chemotherapy was maintained until PD.

Two capsules (one Org 24448 250 mg capsule and one placebo capsule that is identical to the active treatment) will be ingested orally daily for eight weeks.

Two capsules (two Org 24448 250 mg capsules) will be ingested orally daily for eight weeks.

Two capsules (two placebo capsules that are identical to the active treatment) will be ingested orally daily for eight weeks.

Schizophrenia

Org 24448 is a moderate-potency selective AMPA positive modulator that enhances the glutamate system in the brain.

Org 24448

Placebo

UCLA

Maryland Psychiatric Research Center

Massachusetts General Hospital

Harvard Medical School

Washington University School of Medicine

Columbia University Medical Center

Nathan Kline Institute

Duke University Medical Center

Org 24448 (Ampakine) for Cognitive Deficits in Schizophrenia

A Placebo-Controlled Trial of Org 24448 (Ampakine) Added to Atypical Antipsychotics in Patients With Schizophrenia

The MATRICS Consensus Cognitive Battery assesses cognitive function in the following domains: speed of processing, attention/vigilance, verbal learning, visual learning, reasoning and problem solving, and social cognition.

The UPSA assesses skills necessary for functioning in the community by asking patients to perform relevant tasks, rating their performance in five areas: household chores, communication, finance, transportation, and planning recreational activities.

The SCoRS is an assessment of cognitive deficits and the degree to which they affect day-to-day functioning. The items assess the cognitive domains of attention, memory, reasoning and problem solving, working memory, processing speed, language functions, and social cognition.

blister/seizures

Study of Anlotinib Plus Chemoradiotherapy in Patients With Locally Advanced NSCLC

Org 24448 (Ampakine) for Cognitive Deficits in Schizophrenia

A Trial of Antimalarial Drugs Used in Pregnancy in Tanzania

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