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chagas disease/hypoxia
Link salvestatakse lõikelauale
12 tulemused
Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Trypanosoma cruzi (Tc) infection causes chagasic cardiomyopathy; however, why 30-40% of the patients develop clinical disease is not known. To discover the pathomechanisms in disease progression, we obtained the proteome signature of peripheral blood mononuclear cells (PBMCs) of normal healthy
Hypoxia-activated cytotoxicity of benznidazole against clonogenic tumor cells.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Solid tumors contain numerous regions with insufficient oxygen concentrations, a condition termed hypoxia. Tumor hypoxia is significantly associated with metastasis, refractory to conventional cancer therapies, and poor patient survival. Therefore, eradication of hypoxic tumor cells will likely have
Central nervous system involvement in Chagas disease: a hundred-year-old history.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
This review gives an account of central nervous system (CNS) involvement in Chagas disease, as confirmed by pathological studies. The fundamental histopathological finding associated with the acute nervous form of the disease is nodular encephalitis in multiple foci. CNS involvement probably does
Monocyte glycolysis determines CD8+ T cell functionality in human Chagas disease.
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Logi sisse
Chagas disease is a lifelong pathology resulting from Trypanosoma cruzi infection. It represents one of the most frequent causes of heart failure and sudden death in Latin America. Herein, we provide evidence that aerobic glycolytic pathway activation in monocytes drives nitric oxide (NO)
HIF-1α and CD73 Expression in Cardiac Leukocytes Correlates With the Severity of Myocarditis in End-Stage Chagas Disease Patients
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Chronic Chagas cardiomyopathy is the main infectious myocarditis worldwide. Almost 30% of Trypanosoma cruzi infected individuals develop slow and progressive myocarditis that leads to ventricular dilation and heart failure. Heart transplantation is an established, valuable therapeutic option for
Identification of hub genes in chronically hypoxic myocardium using bioinformatics analysis.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Chronic hypoxia can be observed in the heart under physiological or pathophysiological states, including embryonic development or cyanotic congenital heart disease. The aim of the present study was to examine gene expression profiles of chronically hypoxic myocardium and to explore the
Dysregulation of peripheral and central chemoreflex responses in Chagas' heart disease patients without heart failure.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
BACKGROUND
The peripheral and central chemoreflexes are important autonomic mechanisms for regulating breathing and cardiovascular function. Although pathological inflammatory infiltration of the peripheral chemoreceptors and central nervous system has been reported in Chagas' disease, functional
Ischemic cerebral changes in the chronic chagasic cardiopathy.
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Logi sisse
The pathological systematized study of the brain of 31 cases of the chronic cardiac form of Chagas' disease was undertaken. Elective parenchymatous necrosis was found in 64.5% of cases, mainly in cerebellar Purkinje cells, and in thalamic nuclei. Also found were multiple foci of old micronecrosis
[Adenosine induces ventricular arrythmias in hearts with chronic chagas cardiomyopathy].
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Logi sisse
Adenosine released during ischemia and hypoxia can induce ventricular arrhythmias. This phenomenon is also observed in Chagas disease. This study involved pharmacologic analysis of the arrhythmogenic properties of adenosine in healthy Sprague-Dawley rats (n=14) and in rats with chronic Chagas
The anti-protozoan drug nifurtimox preferentially inhibits clonogenic tumor cells under hypoxic conditions.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Tumor hypoxia is an independent prognostic indicator of tumor malignant progression and poor patient survival. Therefore, eradication of hypoxic tumor cells is of paramount importance for successful disease control. In this study, we have made a new discovery that nifurtimox, a clinically approved
Pregnancy in patients with heart disease: experience with 1,000 cases.
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Logi sisse
BACKGROUND
Previously, the high maternal mortality in cardiac patients who became pregnant prompted the assertion: Women with an abnormal heart should not become pregnant. This long-standing notion needs to be revised today.
OBJECTIVE
The study was undertaken to ascertain the experience with a large
Accumulation of brown adipose tissue in patients with Chagas heart disease.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Brown adipose tissue (BAT) is an important source of non-shivering thermogenesis. Increased BAT amounts have been reported to occur in association with several diseases, including congestive heart failure. The objective of the present study was to determine whether BAT accumulation occurs in
Kõige täiuslikum ravimtaimede andmebaas, mida toetab teadus
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