common cold/protease

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6-substituted amino-4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as cysteine protease inhibitors

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BACKGROUND OF THE INVENTION Cysteine proteases, such as cathepsins B, L, S, and O.sub.2, have been implicated in a number of diseases, including cancer metastasis and invasion (Clin. Exp. Metastasis 1992, 10, 145-155; Cancer Metastasis Rev. 1990, 9, 333-352), arthritis (Int. J. Biochem. 1993, 25,

Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses

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SEQUENCE LISTING The nucleic and amino acid sequences listed in the accompanying Sequence Listing are presented in accordance with 37 C.F.R. 1.822. Only one strand of each nucleic acid sequence is shown, but the complementary strand is understood as included by any reference to the displayed strand.

Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses

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SEQUENCE LISTING The nucleic and amino acid sequences listed in the accompanying Sequence Listing are presented in accordance with 37 C.F.R. 1.822. The Sequence Listing is submitted as an ASCII computer readable text file, created on May 1, 2013 as 4 KB, which is incorporated by reference

Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes

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FIELD OF THE INVENTION This invention relates to novel compounds and their pharmaceutically acceptable acid addition salts and base addition salts for use in the treatment of acne, common cold, inflammatory joint disease by inhibition of cysteine proteases and cysteine activity dependent enzymes. In

Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes

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