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coronary thrombosis/tyrosine

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ArtiklidKliinilistes uuringutesPatendid
4 tulemused

Targeting glycoprotein VI and the immunoreceptor tyrosine-based activation motif signaling pathway.

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Logi sisse
Coronary artery thrombosis and ischemic stroke are often initiated by the disruption of an atherosclerotic plaque and consequent intravascular platelet activation. Thus, antiplatelet drugs are central in the treatment and prevention of the initial, and subsequent, vascular events. However, novel

Diverging signaling events control the pathway of GPVI down-regulation in vivo.

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Logi sisse
Coronary artery thrombosis is often initiated by platelet activation on collagen-rich subendothelial layers in the disrupted atherosclerotic plaque. The activating platelet collagen receptor glycoprotein VI (GPVI) noncovalently associates with the Fc receptor gamma-chain (FcRgamma), which signals

Identification of the phosphotyrosine proteome from thrombin activated platelets.

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Logi sisse
Signalling cascades are regulated both positively and negatively by tyrosine phosphorylation. Integrin mediated platelet adhesion triggers signal transduction cascades involving translocation of proteins and tyrosine phosphorylation events, ultimately causing large signalling complexes to be

Vascular Toxicities of Cancer Therapies: The Old and the New--An Evolving Avenue.

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Logi sisse
Since the late 1990s, there has been a steady decline in cancer-related mortality, in part related to the introduction of so-called targeted therapies. Intended to interfere with a specific molecular pathway, these therapies have, paradoxically, led to a number of effects off their intended cancer
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