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8 tulemused
A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Crocus sativus (saffron) is traditionally used to relieve several ailments. Experimental researches have also investigated applications of saffron and its active constituents for the treatment of a wide spectrum of disorders. This review discusses pharmacological/therapeutic properties of
Antiabsence effects of safranal in acute experimental seizure models: EEG and autoradiography.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
OBJECTIVE
We examined the effect of safranal, a constituent of Crocus sativus, in acute experimental animal models of generalized absence seizures.
METHODS
the effect of acute systemic administration of safranal on latency to seizure onset as well as spike and wave discharches (SWD) duration
Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The aim of the present study was to evaluate the effects of safranal, an active constituent of Crocus sativus L. stigmas, on seizures induced by pentylenetetrazol. Intracerebroventricular (i.c.v.) microinjection of safranal (4.84, 9.68 and 24.2 micromol) had no effects on tonic and clonic phases as
Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Safranal, a main component of Crocus sativus, is suggested to have neuroprotective effects. The aim of this study was to investigate the effect of safranal and nanostructured lipid vehicle (NLV) carried safranal in acute and chronic experimental mice models of epilepsy. In PILO acute seizure model,
Plant Polyphenols and Exendin-4 Prevent Hyperactivity and TNF-α Release in LPS-Treated In vitro Neuron/Astrocyte/Microglial Networks.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Increasing evidence supports a decisive role for neuroinflammation in the neurodegenerative process of several central nervous system (CNS) disorders. Microglia are essential mediators of neuroinflammation and can regulate a broad spectrum of cellular responses by releasing reactive oxygen
The Prophylactic and Therapeutic Effects of Saffron Extract and Crocin on Ethanol Withdrawal Syndrome in Mice.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Objectives
Ethanol withdrawal following its chronic use is a serious outcome and challenging to treatment. The chronic use of ethanol induces a progressive neuroplasticity in different reigns of brain. In this study we evaluated the effects of aqueous extract of CrocusCrocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
Crocin is a pharmacologically active carotenoid pigment mainly present in the stigmas of Crocus sativus L. (Iridaceae). It has been well explored in experimental animal models of cognitive impairments, depression, anxiety and epilepsy. This study was designed to understand the effect of crocin on
Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice.
Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
The anticonvulsant activities of Crocus sativus stigma constituents, safranal and crocin, were evaluated in mice using pentylenetetrazole (PTZ)-induced convulsions in mice. Safranal (0.15 and 0.35 ml/kg, i.p.) reduced the seizure duration, delayed the onset of tonic convulsions and protected mice
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