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8 tulemused
Favism: divicine hemotoxicity in the rat.
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Logi sisse
Favism is an acute hemolytic anemia known to occur in susceptible individuals who ingest fava beans. Susceptibility to favism is conferred by a genetic deficiency in erythrocytic glucose-6-phosphate dehydrogenase (G6PD) activity. Although the fava bean pyrimidine aglycones, divicine and isouramil,
Evidence for superoxide generation from the autoxidation of the favism-inducing aglycone divicine.
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Logi sisse
The formation of the superoxide anion radical (O2-) during the autoxidation of divicine, an unstable aglycone involved in the hemolytic anemia occurring in favism, has been demonstrated by EPR with two different procedures. In the first case (chemical method) an O2--mediated reduction of a nitroxide
Effect of the antibiotic neomycin on the toxicity of the glycoside vicine in rats.
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Logi sisse
Vicine is hydrolyzed by microflora to highly reactive free radical generating compound divicine which causes mortality and other adverse effects. This study in the rats established the effect of a broad spectrum and poorly absorbed antibiotic, neomycin sulfate on the toxicity of vicine. The results
Reproductive performance of hens fed field beans and potential relationships to vicine metabolism.
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Logi sisse
Field beans (faba beans, broad beans, horse beans, ackerbohnen, Vicia faba L.) depress weight of eggs when fed to laying hens. Vicine isolated from field beans has been shown to depress egg weight and hatchability when fed in large amounts. The present study was undertaken to determine the effect of
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism.
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Logi sisse
Favism is an acute hemolytic anemia triggered by ingestion of fava beans in genetically susceptible subjects with severe deficiency of glucose-6-phosphate dehydrogenase (G6PD) activity. Erythrocytes from 10 favic patients had constantly and markedly increased calcium levels, as compared with values
A practical toxicity bioassay for vicine and convicine levels in faba bean (Vicia faba).
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Logi sisse
BACKGROUND
Faba bean (Vicia faba) vicine and convicine (V-C) aglycones (divicine and isouramil respectively) provoke an acute hemolytic anemia called favism in individuals with a glucose-6-phosphate dehydrogenase (G6PD) enzyme defect in their red blood cells. Geneticists/plant breeders are working
Irreversible AE1 tyrosine phosphorylation leads to membrane vesiculation in G6PD deficient red cells.
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Logi sisse
BACKGROUND
While G6PD deficiency is one of the major causes of acute hemolytic anemia, the membrane changes leading to red cell lysis have not been extensively studied. New findings concerning the mechanisms of G6PD deficient red cell destruction may facilitate our understanding of the large
Lipids versus proteins as major targets of pro-oxidant, direct-acting hemolytic agents.
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Logi sisse
Lipid peroxidation and the accompanying translocation of phosphatidylserine (PS) from the inner to the outer leaflet of the lipid bilayer have recently been identified as key components of a signaling pathway for phagocytosis of apoptotic cells by macrophages. Drug-induced hemolytic anemia has long
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