Supplementation with Spirulina maxima Supplementation with placebo Group with exercise program and supplementation with Spirulina maxima or placebo (4.5 g/d) in capsules during 6 weeks, then a 2 weeks washout, to finally proceed to the other treatment during 6 more weeks. During the 14 weeks of study duration every participant will have a personal isoenergetic diet.

Supplementation with Spirulina maxima Supplementation with placebo Group without exercise program and supplementation with Spirulina maxima or placebo (4.5 g/d) in capsules during 6 weeks, then a 2 weeks washout, to finally proceed to the other treatment during 6 more weeks. During the 14 weeks of study duration every participant will have a personal isoenergetic diet.

Cardiovascular Diseases

Supplementation with Spirulina maxima (4.5 g/d) in capsules during 6 weeks.

Supplementation with Spirulina maxima

2 weeks washout period to each study subject to avoid any possible carryover effect.

Washout

Supplementation with placebo (4.5 g/d) in capsules during 6 weeks.

Supplementation with placebo

All participants will have a personal isoenergetic diet according to their height, weight, body composition and daily physical activity during 14 weeks

Isoenergetic diet

Participants are going to exercise five days a week with the following protocol: Between 5 and 10 min of heating exercise, Between 20-30 min anaerobic exercise and 20-30 min of aerobic exercise (cardiovascular exercise): walking, jogging, running and/or cycling, Three days a week aerobic intensities will be between 60% and 80% and two days between 70% and 90% of the maximum heart rate reserve, and five final minutes of stretching.

Exercise program

Statistics World Health Organization (WHO)

Universidad Autonoma de Ciudad Juarez

Hypolipidemic and Antioxidant Capacity of Spirulina and Exercise

Independent and Synergistic Effect of Spirulina Maxima With Exercise on General Fitness, Lipid Profile and Antioxidant Capacity in Overweight and Obese Subjects

Change in plasma triacylglycerols, total cholesterol, high density lipoproteins cholesterol, and low density lipoproteins cholesterol after each treatment by using standardized enzymatic methods

Change in maximum oxygen consumption by using a gas analyzer (Cortex Metalizer 3B)

Change in heart rate by using a pulsometer (Polar HT7)

Change in lactate concentration by using an automatized method (YSI lactate analyzer-1600)

Change in body fat mass and body lean mass by using pletysmography (BOD-POD)

Change in blood pressure by using an aneroid sphygmomanometer (Edimetric, Medical Technologies)

Change in malondialdehyde concentration by using standardized specific methods

Change in protein carbonyls concentration by using standardized specific methods

Change in paraoxonase concentration by using standardized specific methods

Change in superoxide dismutase concentration by using standardized specific methods

Change in catalase concentration by using standardized specific methods

Change in glutathione concentration by using standardized specific methods

Change in glutathione reductase concentration by using standardized specific methods

Change in glutathione peroxidase concentration by using standardized specific methods

Heart Failure

High mono-unsaturated fat/low carbohydrate diet

High carbohydrate/low fat diet

Alfred Hospital

Can a Modified Fat Diet With Low Glycaemic Load Improve Insulin Sensitivity and Inflammatory Mediators in Overweight People With Chronic Heart Failure?

dyslipidemias/triacylglycerol

Hypolipidemic and Antioxidant Capacity of Spirulina and Exercise

Can a Modified Fat Diet With Low Glycaemic Load Improve Insulin Sensitivity and Inflammatory Mediators in Overweight People With Chronic Heart Failure?

Liquid Meal Replacements in Conjunction With Lifestyle Intervention in Overweight Adolescents

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