200 mg of Hydroxychloroquine orally three times daily for 10 days plus 500 mg of Nitazoxanide orally twice daily for 6 days

Standard care delivered in the COVID-19 isolation hospitals.

COVID-19

Both hydroxychloroquine & nitazoxanide will be administered orally to participating patients

Hydroxychloroquine plus Nitazoxanide

Oxygen administered via ventilator. In addition, antipyretic "paracetamol" may be added if necessary

Standard care

Hydroxychloroquine and Nitazoxanide Combination Therapy for COVID-19

Clinical Trial Evaluating Safety and Efficacy of Hydroxychloroquine and Nitazoxanide Combination as Adjuvant Therapy in Covid-19 Newly Diagnosed Egyptian Patients: A Tanta University Hope

improved breaths per minute for the patients

Serum iron in microgram/dL of the patients

Serum ferritinin microgram/L of the patients

International normalized ratio "INR" for prothrombin time of 2

CBC for lymphocyte count in cells/microliter

Mortality rate [number of dead patients/total number of treated patients]

Prof. Dr. Kamal Mohammed Okasha

Vice-President of Postgraduate Studies and Research Affairs

Tanta University

a double blind randomized controlled parallel study

Gall Bladder Disease

Gall Bladder Status Among Children With Chronic Haemolytic Anemia

Gall Bladder Status Among Children With Chronic Haemolytic Anemia Attending to Assuit University Children Hospital

Shohnda Mohammed Nazeir

Gall bladder status among children with chronic haemolytic anemia attending to Assiut University children hospital

Assiut University

Method of administration: oral
Dose: 200 mg PO with small sip of water
Known adverse events: yellow discoloration of skin or sclera, 1-10% central nervous system effects including headache and dizziness, GI effect of cramping, < 1% acute renal failure, methemoglobinemia, hemolytic anemia, hepatitis, rash, skin pigmentation, vertigo, stomach cramps
Contraindications: to be used in caution in patients with renal impairment Cr Cl < 50ml/minute and in patients who are receiving nitric oxide, prilocaine and sodium nitrite as it can cause methemoglobinemia

Method of administration: intravenous
Dose: 25 mg
Known adverse events: nausea, vomiting, flushing or rash, hypersensitivity and anaphylactic reactions can occur following injection and immediate treatment with epinephrine should be available, skin and urine discoloration (urine may appear bright yellow for 24-36 hours), extravasation may cause skin sloughing, toxic neuritis and phlebitis, nausea, rare cardiac arrest and seizure,
Contraindications: use with caution in patients with history of hypersensitivity, allergies or asthma

Method of administration: irrigant during cystoscopy
Dose: 300cc during cystoscopy to visualize the ureters
Known adverse events: dysuria, polyuria, hyponatremia with excess absorption, potential increased risk of urinary tract infection
Contraindications when used as a genitourinary irrigation solution: anuria

Method of administration: irrigant during cystoscopy
Dose: 300cc
Known adverse events: no known significant adverse events
Contraindications: none

Method of administration: oral
Dose: 200 mg PO with small sip of water
Known adverse events: yellow discoloration of skin or sclera, 1-10% central nervous system effects including headache and dizziness, GI effect of cramping, < 1% acute renal failure, methemoglobinemia, hemolytic anemia, hepatitis, rash, skin pigmentation, vertigo, stomach cramps
Contraindications: to be used in caution in patients with renal impairment Cr Cl < 50ml/minute and in patients who are receiving nitric oxide, prilocaine and sodium nitrite as it can cause methemoglobinemia
Pyridium

A- Pyridium

Method of administration: intravenous
Dose: 25 mg
Known adverse events: nausea, vomiting, flushing or rash, hypersensitivity and anaphylactic reactions can occur following injection and immediate treatment with epinephrine should be available, skin and urine discoloration (urine may appear bright yellow for 24-36 hours), extravasation may cause skin sloughing, toxic neuritis and phlebitis, nausea, rare cardiac arrest and seizure,
Contraindications: use with caution in patients with history of hypersensitivity, allergies or asthma
Sodium Fluorescein

B- Sodium Fluorescein

Method of administration: irrigant during cystoscopy
Dose: 300cc during cystoscopy to visualize the ureters
Known adverse events: dysuria, polyuria, hyponatremia with excess absorption, potential increased risk of urinary tract infection
Contraindications when used as a genitourinary irrigation solution: anuria
Mannitol

C- Mannitol

Method of administration: irrigant during cystoscopy
Dose: 300cc
Known adverse events: no known significant adverse events
Contraindications: none
Normal Saline

Control- Normal Saline

Total

Age, Customized

Sex: Female, Male

Race/Ethnicity, Customized

This is a 10-cm visual analog scale to determine which method of evaluating ureteral patency is most satisfactory to physicians. The smiley face is at one end and the frowning face is at the other end. Smiling is 1 and frowning is 10. The scale is completed by surgeon, anesthesiologist and the circulator by placing an "x" or a "mark" anywhere on the 10 cm line towards how good and or bad each person felt about the of process of patency assessment that was used. Using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the "no pain" anchor and the patient's mark, providing a range of scores from a minimum of 0 to a maximum of 100. A higher score indicates greater pain intensity (worse outcome).

Visual Analog Scale (VAS)

Overall Study

Nisha Philip, Clinical Research Manager

Ureteral Patency

Pyridium

Sodium Fluorescein

Mannitol

Normal Saline

Columbia University Medical Center

Evaluation of Ureteral Patency in the Post-indigo Carmine Era

Columbia University

Fortrans (split dose) + Mentholyptus drops

Bowel Cleansing in Preparation for Colonoscopy

preparation cleaning solution

American University of Beirut Medical Center

PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation

PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation: A Randomised Controlled Study

Superiority of Fortrans + Halls to MoviPrep in cleansing the bowels

glucose 6 phosphate dehydrogenase/iiveldus

Hydroxychloroquine and Nitazoxanide Combination Therapy for COVID-19

Gall Bladder Status Among Children With Chronic Haemolytic Anemia

Evaluation of Ureteral Patency in the Post-indigo Carmine Era

PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation

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