Metabolic Syndrome

Chronic Fatigue Syndrome

Premature Aging

RiaGev

Prism Research, Inc.

The Safety and Efficacy Study of RiaGev in Healthy Adults

A Randomized, Double-blind, Comparator-controlled, Cross-over Study to Investigate the Safety and Efficacy of RiaGev™ in Healthy Adults

The change in whole blood NAD+ levels from baseline to day 8 when supplemented with RiaGev™ or comparator. The parameter is measured at Day 1, Day 3, Day 5, and Day 8.

The change in serum glucose as assessed by an Oral Glucose Tolerance Test (OGTT) at t=0, 15m, 30, 45m, 60m, 90m and 2h after a 7-day supplementation with either RiaGev™ or comparator. The measure will take place on Day 1 and Day 8

The change in serum insulin as assessed by an Oral Glucose Tolerance Test (OGTT) at t=0, 15m, 30, 45m, 60m, 90m and 2h after a 7-day supplementation with either RiaGev™ or comparator. The measurement take place on Day 1 and Day 8.

The change in serum Glutathione/Glutathione disulfide (GSH/GSSG) ratio after a 7-day supplementation with either RiaGev™ or comparator. The measurement take place on Day 1 and Day 8, before and after exercise.

The change in serum adenosine triphosphate/ adenosine monophosphate (ATP/AMP) ratio after a 7-day supplementation with either RiaGev™ or comparator. The measurement take place on Day 1, Day 3, Day 5, and Day 8.

The change in salivary cortisol after a 7-day supplementation with either RiaGev™ or comparator. The measurement take place on Day 1, 3, 5, and 8.

The change in Checklist Individual Strength (CIS) Questionnaire outcome after a 7-day supplementation with either RiaGev™ or comparator. There are twenty question categorized into four categories, including fatigue, concentration, motivation, and physical activity. The total as well as category score will be reported.

Incidence of pre-emergent and post-emergent adverse events when supplemented

Clinical chemistry parameters including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, creatinine, electrolytes (Na, K, Cl), fasting glucose, and estimated glomerular filtration rate (eGFR). The number of out of norm incidence will be reported.

Hematology parameters including white blood cell (WBC) count with differential (neutrophils, lymphocytes, monocytes, eosinophils, basophils), red blood cell (RBC) count, hemoglobin, hematocrit, platelet count, RBC indices (mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), The number of out of norm incidence will be reported

Vital signs including blood pressure (BP) and heart rate (HR) are going to be measured. Out of norm incidence will be reported.

Bioenergy Life Science, Inc.

KGK Science Inc.

University of Washington

randomized, double-blind, comparator-controlled, cross-over

Gall Bladder Disease

Gall Bladder Status Among Children With Chronic Haemolytic Anemia

Gall Bladder Status Among Children With Chronic Haemolytic Anemia Attending to Assuit University Children Hospital

Shohnda Mohammed Nazeir

Gall bladder status among children with chronic haemolytic anemia attending to Assiut University children hospital

Assiut University

Laboratory investigations :
complete blood count
renal and liver function tests
serum ferritin
lipid profile
Interleukin -6
HsC-RP
Adiponectin level
Imaging :
Abdominal ultrasound
Echocardiography
Carotid intima media thickness

Thalassemia

serum samples used for doing the test by ELISA

Interleukin-6

HsC-RP

Adiponectin level

Carotid intima media thickness

Assiut University Hospital

Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Adiponectin, Interleukin-6 (IL-6) and High Sensitive C-reactive Protein (hsC-RP) in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Asmaa Nady Hussein

Principal investigator

Blood and tissue samples(adipose, omentum and liver biopsies)

Diabetes

Obesity

Mobile Infirmary Medical Center

University of South Alabama

Erythrocyte and Adipocyte G6PD Activity Levels in Obesity

Erythrocyte and Adipocyte G6PD Activity Levels Correlate With Differing Degrees of Dyslipidemia, Insulin Resistance and Obesity

G6PD levels will be measured at the following time intervals: Baseline(prior to gastric bypass surgery), 1 week, 6 weeks, 12 weeks, 6 months, 12 months and 24 months post surgery.

glucose 6 phosphate dehydrogenase/rasvumus

The Safety and Efficacy Study of RiaGev in Healthy Adults

Gall Bladder Status Among Children With Chronic Haemolytic Anemia

Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Erythrocyte and Adipocyte G6PD Activity Levels in Obesity

Epidemiology of Insulin and Dehydroepiandrosterone Sulfate and Coronary Heart Disease Mortality

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