Composition for use as a pulpotomy agent having glutaraldehyde as the active ingredient in a solution stabilized by a buffer suitable for maintaining the pH of the glutaraldehyde solution at near-physiological levels. The stable composition also includes the anti-oxidants sodium nitrite and glycerol. The composition is used by direct application to infected coronal pulp tissue to fix the tissues and prevent further deterioration caused by pulpitis. A method of treating the infected tissue prior to dental restoration is also disclosed.

Biomedical Development Corporation

Pulpotomy agent and method of use

Described herein are routes of synthesis and therapeutic uses of 1-alkyl, 2-acyl glycerol derivatives of formula I: which when administered to mammalian biological systems result in increased cellular concentrations of specific sn-2 substituted ethanolamine plasmalogens independent of the ether lipid synthesis capacity of the system. Elevating levels of the specific sn-2 substituted species in this way can cause lowering of membrane cholesterol levels and the lowering of amyloid secretion. These compounds can be used for the treatment or prevention of diseases of aging associated with increased membrane cholesterol, increased amyloid, and decreased plasmalogen levels, such as neurodegeneration (including Alzheimer's disease, Parkinson's disease and age-related macular degeneration), cognitive impairment, dementia, cancer (e.g. prostate, lung, breast, ovarian, and kidney cancers), osteoporosis, bipolar disorder and vascular diseases (such as atherosclerosis, hypercholesterolemia). ##STR00001##

Khan; M. Amin

Wood; Paul L.

Goodenowe; Dayan

Mankidy; Rishikesh

Ahiahonu; Pearson

Phenomenome Discoveries Inc.

Plasmalogen compounds, pharmaceutical compositions containing the same and methods for treating diseases of the aging

glycerol

atrophy

glycerol/atrophy

Pulpotomy agent and method of use

Plasmalogen compounds, pharmaceutical compositions containing the same and methods for treating diseases of the aging

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