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Hypertension Management in Cancer Patients

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This is a 12-week prospective study with two phases. In Phase 1 (Weeks 1-4), participants will self-monitor their blood pressure using the Qardio bluetooth device. In Phase 2 (Weeks 5-12), the investigators will implement the auto-messaging system triggered by a weekly average systolic blood

Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease

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Idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder of unknown etiology, characterized by bradykinesia (slowness of movements) associated with tremor at rest and/or muscle rigidity. PD is typically associated with a significant loss of dopaminergic neurons in the

Cardiac Changes in Myeloproliferative Neoplasms

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According to worldwide study of prevalence of myeloproliferative neoplasms revealed: Incidence of polycythemia vera ranged 0.01 to 2.61 per 100.000 population and the prevalence ranging from 0.49 to 46.88 per 100.000 population. Incidence of essential thrombocythemia is 0.21 to 2.27 per 100.000

Correlation Between PTP1B Expression and Organ Failure During Sepsis

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Angiogenesis and Fibrosis in Myocardial Infarction

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Integrins are a group of molecules responsible for intercellular adhesion and signalling. They comprise a superfamily of heterodimeric receptors that are composed of 18 different α and β subunits. In combination, they can generate 24 different receptor subtypes with a range of physiological and

Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell Disease

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Sickle Cell Disease related pulmonary hypertension is a heterogeneous condition that results in a high mortality and for which no therapy has been documented to be beneficial. We propose to perform a safety and tolerability study of treatments based on right heart catheterization derived hemodynamic

Sunitinib and Atrial Trabeculae Contractility

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Study population: 44 (+22) patients undergoing CABG cardiac surgery with extracorporal circulation Intervention (if applicable): none (pharmacological interventions will only be performed ex-vivo in isolated atrial tissue) Main study parameters/endpoints The developed force in ex vivo atrial

Unrelated Umbilical Cord Blood Transplantation With Coinfusion of Mesenchymal Stem Cells

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PROTOCOL SYNOPSIS Title of the study A pilot study to assess the feasibility of unrelated umbilical cord blood transplantation with coinfusion of third-party mesenchymal stem cells after myeloablative or nonmyeloablative conditioning in patients with hematological malignancies. Design of the study

Molecular Mechanisms of Type 2 Diabetes Mellitus

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Specific Aims To test the global hypothesis that increases in insulin signaling through either PI-3-kinase or MAP kinase pathways correlate with improvements in NO production or NOS expression in skeletal muscle following pioglitazone therapy, we will determine whether 6 months of Pioglitazone

Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR)

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Study Focus and Design: Breast cancer is one of the leading cancers among white and African American women; its incidence has increased from one in 20 in 1960 to one in eight today ARMSTRONG 2000. In Canada alone, approximately 22,000 women are diagnosed each year with breast cancer and over 5,000

Anti-inflammatory Therapy With Anakinra in Newly Diagnosed Type 1 Diabetes

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Type 1 diabetes mellitus (T1D) is caused by autoimmune and autoinflammatory destruction of the insulin-producing beta cells in the pancreatic islets of Langerhans. Historically, treatment for this condition has consisted of insulin replacement therapy and dietary modification. Recent studies have

Safety Study of Gleevec® in Children With Pulmonary Hypertension

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Idiopathic pulmonary artery hypertension (IPAH) is a rare but progressive disease in children and adults with a very high mortality from right heart failure. Platelet derived growth factor (PDGF) has been implicated in the pulmonary artery remodeling and vascular proliferation that is a pathologic

Imatinib Mesylate in Combination With Docetaxel for Advanced, Platinum-Refractory Ovarian Cancer

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OUTLINE: This is a multi-center study. Submit tumor and serum samples for central review - Imatinib 600 mg (orally qd); - Docetaxel 30mg/m2 (4 of 6 weeks);1 cycle = 6 weeks - Evaluate every other cycle Each cycle will begin only when the granulocyte count is > 1,500/mm3 and the platelet count is >

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