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Treatment with recombinant tissue plasminogen activator (rt-PA) is the most effective therapeutic option against brain ischemic stroke at the present time. However, elevated incidence of symptomatic intracerebral hemorrhage (SIH) greatly hinders ideal treatment outcome of rt-PA. We sought to assess
Of 61 horses with a history of exercise-induced pulmonary hemorrhage and treated with furosemide 4 hours prior to racing, 34 (55.7%) continued to bleed. Of 24 horses with exercise-induced pulmonary hemorrhage that were not treated with furosemide prior to racing, 17 (70.8%) still bled. There was no
We examined the protective effects of hesperidin on cerebral vasospasm by establishing an experimental rat model of subarachnoid haemorrhage and performing biochemical, pathological and histomorphometric analysis on these data. Forty albino Wistar rats were randomly divided into five groups of n = 8
OBJECTIVE
To inform of the use of the Flavonoids in the treatment of bladder varicose veins, and their effectiveness.
METHODS
It is informed of 4 cases that went for haematuria, and that in the cystoscopy one observes bladder varicose veins, bleeding in 2 cases, in them you uses Hesperidina 150 mg
To evaluate immunomodulating activities of bioflavones, colony-stimulating factor (CSF)-inducing activity of two dihydroflavones, three flavones and three flavonols were tested. These samples were suspended in saline and injected intraperitoneally (i.p.) into mice at a dose of 1 mg 6 h before
The aim of this study was to explore the role of hesperadin in intracerebral hemorrhage (ICH) mice, with the involvement of the mammalian ste20-like kinase 4 (MST4)/AKT signaling pathway.All mice were divided into four groups: sham group, sham+hesperidin BACKGROUND
CCl4 is a well-established hepatotoxin inducing liver injury by producing free radicals. Exposure to CCl4 also induces acute and chronic renal injuries. The present study was designed to establish the protective effect of hesperidin (HDN), a citrus bioflavonoid, on CCl4-induced oxidative
Spinal cord injury (SCI) is associated with inflammation with concurrent oxidative stress and glial activation. The aim of this study was to evaluate whether hesperidin, a representative flavonoid in citrus fruits, ameliorates SCI-induced motor dysfunction and neuro-pathologic degeneration in rat
The objective of this article is to analyze the effects of nerolidol and hesperidin treatment on surgically induced endometriosis in a rat model. Endometriosis was induced in 24 healthy adult female Wistar albino rats via homologous uterine horn transplantation. Three operations were performed on
A prospective randomized controlled trial was carried out on the effects of Daflon 500 mg (a micronized flavonidic fraction containing diosmin 450 mg and hesperidin 50 mg) on bleeding after haemorrhoidectomy. In all, 228 consecutive patients with prolapsed irreducible piles were recruited. Elective
BACKGROUND
The role of a mixture of phlebotonics in the treatment of acute hemorrhoid crisis is investigated to test their efficacy.
METHODS
One hundred and thirty-four consecutive patients with an acute hemorrhoidal crisis recruited in five colorectal units entered the study. Sixty-six of them were
OBJECTIVE
We evaluated the efficacy of new flavonoids mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) to reduce bleeding from I-III degrees hemorrhoidal disease in the short and medium time.
METHODS
One hundred fifty-four consecutive patients with hemorrhoidal disease recruited in four
The efficacy and safety of a new veno-active flavonoid fraction (S 5682) consisting of micronized diosmin (90%) and hesperidin (10%) have been studied in 100 patients with symptomatic capillary fragility in a double-blind, randomized, placebo-controlled trial. Treatment lasted 6 weeks and consisted
The most significant complication of liver cirrhosis is the syndrome of portal hypertension. Varicose veins of the esophagus and stomach diagnosed in 50-80% of patients with liver cirrhosis and complicated by hemorrhage in 30-50%. The risk of bleeding is determined by the size of varicose veins,