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inflammation/oksendamine

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Leht 1 alates 127 tulemused

Treatment of emesis with morpholine tachykinin receptor antagonists

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Logi sisse
SUMMARY OF THE INVENTION This invention is concerned with novel compounds represented by structural formula I: ##STR2## wherein R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.11, R.sup.12, R.sup.13, A, B, p, Y and Z are hereinafter defined. The invention is also concerned with pharmaceutical

Pharmaceutical agents for the treatment of emesis

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BACKGROUND OF THE INVENTION The present invention relates to a novel process for preparing and resolving 3-amino-2-phenylpiperidine and for synthesizing from the enantiomers of such compound certain pharmaceutically active substituted 2-phenyl-3-benzylaminopiperidines. The substituted

Benzoimidazole derivatives and pharmaceutical composition comprising the same

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TECHNICAL FIELD The present invention relates, in general, to novel benzoimidazole derivatives and, more particularly, to novel benzoimidazole derivatives functioning as antagonists to a vanilloid receptor (capsaicin receptor; Transient Receptor Potential Channel, Vanilloid subfamily member 1;

Azabicyclic amine derivatives and their use as therapeutic agents

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CROSS REFERENCE TO RELATED APPLICATIONS This application claims priority under 35 U.S.C. .sctn.119 from GB Application No. 0108971.3, filed Apr. 10, 2001. The present invention provides compounds of the formula (I): ##STR2## wherein X represents hydrogen or a C.sub.1-4 alkyl group optionally

Tetrahydropyran derivatives and their use as therapeutic agents

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Logi sisse
This invention relates to a class of tetrahydropyran compounds which are useful as tachykinin antagonists. More particularly, the compounds of the invention are useful as neurokinin 1 (NK-1) receptor antagonists. By virtue of their excellent specificity for the human NK-1 receptor, the compounds of

Morpholine derivatives and their use as therapeutic agents

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Logi sisse
This invention relates to a class of morpholine derivatives which are useful as tachykinin antagonists. The tachykinins are a group of naturally occurring peptides found widely distributed throughout mammalian tissues, both within the central nervous system and in peripheral nervous and circulatory

Benzoamide piperidine containing compounds and related compounds

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Logi sisse
The present invention relates to certain benzoamide piperidine containing compounds and related compounds that exhibit activity as NK-1 receptor antagonists, (e.g., substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of

Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44)

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Logi sisse
FIELD OF THE INVENTION This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists

Modulation of substance P by compounds containing calcium sulfate and methods relating thereto

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TECHNICAL FIELD The present invention relates generally to a method of modulating substance P by compounds containing calcium sulfate, particularly syngenite, gorgeyite and gypsum, and more specifically, to the synthesis of such compounds as well as their use to treat a variety of conditions

Therapeutic agents useful for treating pain

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Logi sisse
1. FIELD OF THE INVENTION The present invention relates to Cyanoiminopiperazine Compounds, compositions comprising an effective amount of a Cyanoiminopiperazine Compound and methods for treating or preventing pain, urinary incontinence (UI), an ulcer, inflammatory-bowel disease (IBD),

Therapeutic agents useful for treating pain

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
1. FIELD OF THE INVENTION The present invention relates to Cyanoiminopiperazine Compounds, compositions comprising an effective amount of a Cyanoiminopiperazine Compound and methods for treating or preventing pain, urinary incontinence (UI), an ulcer, inflammatory-bowel disease (IBD),

Therapeutic agents useful for treating pain

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Logi sisse
1. FIELD OF THE INVENTION The present invention relates to 3-substituted Pyridyl Compounds, compositions comprising an effective amount of a 3-substituted Pyridyl Compound and methods for treating or preventing a condition such as pain comprising administering to an animal in need thereof an

Therapeutic agents useful for treating pain

Ainult registreeritud kasutajad saavad artikleid tõlkida
Logi sisse
1. FIELD OF THE INVENTION The present invention relates to 3-substituted Pyridyl Compounds, compositions comprising an effective amount of a 3-substituted Pyridyl Compound and methods for treating or preventing a condition such as pain comprising administering to an animal in need thereof an

Tetrazolyl-substituted quinuclidines as substance P antagonists

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Logi sisse
TECHNICAL FIELD This invention relates to novel tetrazolyl-substituted quinuclidine compounds and their pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and the use of such compounds as substance P antagonists. BACKGROUND ART Substance P is a naturally

Aprepitant L-proline solvates--compositions and cocrystals

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FIELD OF THE INVENTION The invention relates to a new aprepritant compositions and crystalline compounds containing aprepitant. More particularly, the invention relates to solvated aprepitant L-proline solvate compositions, aprepitant L-proline solvate cocrystals, therapeutic uses of the aprepitant
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