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lactate dehydrogenase/sarcoma

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Leht 1 alates 147 tulemused
An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase associated with Kirsten murine sarcoma virus (LDHk) was found in the sera of many patients with malignant tumors, while the sera of healthy persons had little or no such activity. This isozyme was detectable only when assayed in a

[Lactate dehydrogenase isoenzyme in Rous sarcoma and muscle tissue of tumor-bearing hens].

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Logi sisse
The isoenzymic spectrum and lactate dehydrogenase activity (LDH) were studied in tumor and pectoral muscle of both chicken and adult hens on the 6th, 10th and 15th day after their infection with the Rous sarcoma virus. On the 14th day, unlike the muscles of intact hens, in the tumour the content of
A novel isozyme of lactate dehydrogenase is detected in various cells transformed by the Kirsten murine sarcoma virus (KiMSV). This isozyme, designated LDHk, is strongly inhibited by physiological concentrations of oxygen, in an apparently cooperative fashion. LDHk is inhibited by guanosine

LDHk, the lactate dehydrogenase associated with transformation by the Kirsten sarcoma virus: a re-evaluation.

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Logi sisse
A lactate dehydrogenase isozyme designated "LDHk" has recently been described in cells transformed by the Kirsten murine sarcoma virus. Several unusual properties were felt to distinguish this LDH isozyme from previously described LDH isozymes. These properties include cathodic electrophoretic
The enhancement of Moloney murine sarcoma virus (M-MuSV) tumor growth in BALB/c mice previously infected with lactate dehydrogenase virus (LDV) was shown to depend on the timing of the inoculations. Mice infected with LDV either 3 or 4 days prior to the M-MuSV inoculations demonstrated enhanced
OBJECTIVE This study aimed to determine the expression of lactate dehydrogenase (LDH)-A and LDH-D in patients with uterine myoma, cellular leiomyoma (CLM), and uterine sarcoma and to evaluate their prognostic significance. METHODS Protein expression levels of LDH-A and LDH-D were determined in

SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA.

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Logi sisse
OBJECTIVE To study the relationship between the serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) in patients with Ewing´s Sarcoma (ES) . METHODS This is a case series with retrospective evaluation of patients with diagnosis of ES
Altered cellular metabolism, including an increased dependence on aerobic glycolysis, is a hallmark of cancer. Despite the fact that this observation was first made nearly a century ago, effective therapeutic targeting of glycolysis in cancer has remained elusive. One potentially promising approach

Overcoming cetuximab resistance in Ewing's sarcoma by inhibiting lactate dehydrogenase-A.

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Logi sisse
Ewing's sarcoma, the second most common type of malignant bone tumor, generally occurs in children and young adults. The current treatment of Ewing's sarcoma comprises systemic anti‑cancer chemotherapy with complete surgical resection. However, the majority of patients with Ewing's sarcoma develop

Pretreatment serum lactate dehydrogenase predicting metastatic spread in Ewing's sarcoma.

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We measured serum lactate dehydrogenase levels in 36 patients with localized Ewing's sarcoma before treatment. The results were evaluated to determine if the levels served as a prognostic indicator for metastatic spread. After adjusting for primary site of disease and adjuvant chemotherapy, the
OBJECTIVE To establish the clinical utility of serum soluble IL-2 receptor (sIL-2R alpha), lactate dehydrogenase (LDH) [corrected] and B2-microglobulin [corrected] (B2-M) as markers for diagnosis, prognosis and treatment monitoring in childhood soft tissue sarcomas (STS). METHODS The

Prognostic significance of serum lactate dehydrogenase levels in Ewing's sarcoma: A meta-analysis.

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Logi sisse
A number of studies have investigated the role of serum lactate dehydrogenase (LDH) levels in patients with Ewing's sarcoma, although these have yielded inconsistent and inconclusive results. Therefore, the present study aimed to systematically review the published studies and conduct a
Many components of oncologic treatment increase serum sIL-2Rα level, which may falsely suggest a relapse. We tried to establish whether granulocyte colony stimulating factor (G-CSF) and central vein catheter (CVC)-related sepsis increase serum sIL-2Rα level to values on relapse of childhood soft

Serum lactate dehydrogenase (LDH) as a tumor marker in Ewing's sarcoma.

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The pretreatment serum lactic acid dehydrogenase (LDH) level of 246 patients with Ewing's sarcoma of bone (47 metastatic and 199 localized at presentation) was examined to evaluate the use of LDH as a tumor marker. The percentage of patients with increased serum LDH levels was significantly higher
The aim of the present study was to determine whether serum lactate dehydrogenase (LDH) levels before treatment could predict the disease-specific and event-free survival in adult patients with STS.A total of 142 adult patients with primary STS were
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