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Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies.

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Extracts of milk thistle have been recognized for centuries as "liver tonics" and are well-known to prevent or reverse hepatotoxicity of reactive drug metabolites or naturally occurring toxins. Milk thistle extracts are now under intense study in the experimental therapeutics of cancer for

Silymarin and Its Role in Chronic Diseases.

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Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. Milk thistle has a lot of traditional values, being used as a vegetable, as salad, as bitter tonic, and as galactogogue in nursing mothers and in various ailments such as liver

Milk thistle and its derivative compounds: a review of opportunities for treatment of liver disease.

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Milk thistle extracts have been used as a "liver tonic" for centuries. In recent years, silibinin, the active ingredient in milk thistle extracts, has been studied both in vitro and in vivo to evaluate the beneficial effects in hepatic disease. Silibinin increases antioxidant concentrations and

Alternative therapy use in liver transplant recipients.

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BACKGROUND The extent of use of alternative therapies and the psychosocial variables predictive of their use have not been well defined in liver transplant recipients. OBJECTIVE To determine types of alternative therapies used by liver transplant recipients and to assess psychosocial, behavioral,

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury

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Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as an herbal for treatment of liver conditions. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute

An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome.

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BACKGROUND Metabolic syndrome is the cluster of risk factors that leads to increased episodes of cardiovascular disease (CVD). These risk factors include but are not limited to obesity, non-alcoholic fatty liver (NAFLD), dyslipidemia, and type 2 diabetes. Since the pathogenesis of metabolic syndrome

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