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Leht 1 alates 254 tulemused
Oxidized amino acids in lens protein with age. Measurement of o-tyrosine and dityrosine in the aging human lens.
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The concentrations of ortho-tyrosine (o-Tyr) and dityrosine (DT) were measured in noncataractous human lenses in order to assess the role of protein oxidation reactions in the aging of lens proteins. The measurements were conducted by selected ion monitoring-gas chromatography/mass spectrometry
Ras signaling is essential for lens cell proliferation and lens growth during development.
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The vertebrate ocular lens is a simple and continuously growing tissue. Growth factor-mediated receptor tyrosine kinases (RTKs) are believed to be required for lens cell proliferation, differentiation and survival. The signaling pathways downstream of the RTKs remain to be elucidated. Here, we
Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract.
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Cataract is a common age-related condition that is caused by progressive clouding of the normally clear lens. Cataract can be effectively treated by surgery; however, like any surgery, there can be complications and the development of a secondary cataract, known as posterior capsule opacification
18 kDa protein tyrosine phosphatase in the ocular lens.
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Protein tyrosyl phosphorylation and dephosphorylation play essential roles in regulating cellular events such as proliferation and differentiation, and their involvement in the lens development and transparency is also suggested. The level of tyrosine phosphorylation in a given protein is regulated
Reaction of tyrosine oxidation products with proteins of the lens.
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Oxidation of tyrosine in the presence of bovine lens proteins leads to the formation of brown or black melanoproteins. Both tyrosinase and the oxidizing system of ferrous sulphate-ascorbic acid-EDTA are effective. The fluorescence of the lens proteins is both altered and enhanced by the
Identification of receptor tyrosine kinases in the embryonic chicken lens.
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Protein phosphorylation plays a critical role in the control of growth and regulation of many eukaryotic cells. Members of the protein tyrosine kinase (PTK) family of peptides function as growth factor receptors and oncoproteins. A common feature of members of the PTK family is a highly conserved
Raman spectroscopic study of age-related structural changes in the lens proteins of an intact mouse lens.
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Age-related structural changes in the lens proteins of a normal mouse lens have been monitored in situ by laser Raman spectroscopy. The Raman spectrum of an ICR-strain mouse lens nucleus showed virtually no change in the 550-850- and 900-1800-cm-1 regions as the mouse aged. Lens aging, however, did
Calcium mobilisation modulates growth of lens cells.
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The modulating effect of calcium cell signalling agonists on tissue growth was studied in a rabbit lens cell line (NN1003A). Calcium mobilisation was measured after Fura-2 incorporation and growth assayed either by direct Coulter counting or [3H]-thymidine incorporation. Transient increases in
The hydroxyl radical in lens nuclear cataractogenesis.
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Cataract is the major cause of blindness; the most common form is age-related, or senile, cataract. The reasons for the development of cataract are unknown. Here we demonstrate that nuclear cataract is associated with the extensive hydroxylation of protein-bound amino acid residues, which increases
Glutathione levels of the human crystalline lens in aging and its antioxidant effect against the oxidation of lens proteins.
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This paper reports the role of glutathione (GSH) in the crystalline lens as an antioxidant against the oxidation of lens protein. GSH levels in normal lenses decreased gradually with increasing age, from approximately 5 mumol per g lens (wet weight) to 3 mumol per g lens (wet weight). On the other
Conformational changes in human lens proteins in cataract.
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The reactivity of protein thiol groups in human lens and the susceptibility of the proteins to tryptic digestion were investigated. Both were found to be greater in some cataractous lenses, indicating that lens proteins have unfolded during cataractogenesis. Almost all the tyrosine in the proteins
The lens epithelium in ocular health and disease.
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The lens arises from invagination of head ectoderm during embryonic development and in the adult has a relatively simple structure, comprising just two cell types (epithelial and fibre cells). Its isolation from nerves and blood vessels in the adult make it a tractable model to investigate
Studies of tyrosine phosphorylation and Src family tyrosine kinases in the lens epithelium.
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OBJECTIVE
Tyrosine phosphorylation regulates many aspects of cell function; thus, cells that have different roles often display different patterns of tyrosine phosphorylation. Because there is interest in differential function of the anterior and equatorial regions of the lens epithelium, studies
Calcium activates SK channels in the intact human lens.
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OBJECTIVE
Apamin-sensitive, calcium-activated SK potassium channels have been implicated in schizophrenia and myotonic dystrophy (MD), and both conditions carry an increased risk of cataract. The presence and functional activity of SK channels were therefore investigated in the human
A lens intercellular junction protein, MP26, is a phosphoprotein.
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The major protein present in the plasma membrane of the bovine lens fiber cell (MP26), thought to be a component of intercellular junctions, was phosphorylated in an in vivo labeling procedure. After fragments of decapsulated fetal bovine lenses were incubated with [32P]orthophosphate, membranes
Kõige täiuslikum ravimtaimede andmebaas, mida toetab teadus
- Töötab 55 keeles
- Taimsed ravimid, mida toetab teadus
- Maitsetaimede äratundmine pildi järgi
- Interaktiivne GPS-kaart - märgistage ürdid asukohas (varsti)
- Lugege oma otsinguga seotud teaduspublikatsioone
- Otsige ravimtaimi nende mõju järgi
- Korraldage oma huvisid ja hoidke end kursis uudisteuuringute, kliiniliste uuringute ja patentidega
Sisestage sümptom või haigus ja lugege ravimtaimede kohta, mis võivad aidata, tippige ürdi ja vaadake haigusi ja sümptomeid, mille vastu seda kasutatakse.
* Kogu teave põhineb avaldatud teaduslikel uuringutel
