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lipoxygenase/insult
Link salvestatakse lõikelauale
9 tulemused
1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase
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FIELD OF THE INVENTION
The present invention provides inhibitors of the enzyme 15-lipoxygenase, pharmaceutical compositions comprising said inhibitors, and methods of treating diseases responsive to inhibition of 15-lipoxygenase.
BACKGROUND OF THE INVENTION
Hypercholesterolemia can induce monocytes
Inhibitors of human 12/15-lipoxygenase
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TECHNICAL FIELD
The present invention relates generally to inhibition of 12/15-lipoxygenase, treatment of a condition involving 12/15-lipoxygenase including, but not limited to, strokes, periventricular leukomalacia, cardiac arrest with resuscitation, atherosclerosis, Parkinson's disease,
Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
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BACKGROUND OF THE INVENTION
Myocardial infarction (MI) is one of the most common diagnoses in hospitalized patients in industrialized countries. Myocardial Infarction generally occurs when there is an abrupt decrease in coronary blood flow following a thrombotic occlusion of a coronary artery
Substituted heteroaryl analogs of 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
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BACKGROUND OF THE INVENTION
The present invention is novel compounds which are 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidine substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical
Substituted 4,6-di-tertiary-butyl 5-hydroxy-pyrimidines
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BACKGROUND OF THE INVENTION
The present invention is novel compounds which are 4,6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidine substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical
Substituted chromans and their use in the treatment of asthma, arthritis and related diseases
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BACKGROUND OF THE INVENTION
The present invention is directed to substituted chromans of the formula (I), depicted below, which by inhibiting 5-lipoxygenase enzyme are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction, stroke and related disease
12 (S)--hete receptor blockers
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to blockade of the 12(S)-HETE cell surface receptor as a treatment for conditions of the body which result from stimulation or overstimulation of the receptor. 12(S)-HETE, a product of the 12-lipoxygenase pathway,
6,5-Fused bicyclic heterocycles
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FIELD OF THE INVENTION
The invention provides 6,5-fused bicyclic compounds, pharmaceutical compositions thereof, and methods of making and using such compounds and compositions to inhibit the 15-lipoxygenase enzyme, and thus treat diseases with an inflammatory component
BACKGROUND OF THE
Use of flap inhibitors to reduce neuroinflammation mediated injury in the central nervous system
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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH
None.
TECHNICAL FIELD
This invention relates generally to a method of treating neuroinflammation and neuroinflammation mediated injury resulting from various brain injury events such as traumatic brain injury, stroke, multiple sclerosis, Alzheimer's
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