Multiple Sclerosis

Motor assessment includes:
posturographic examination in Single-task (ST) and Double-task (DT)
an analysis of ST and DT walking;
Timed Up and Go (TUG) performances in real (rTUG) and imagined (iTUG) versions;

Dual TAsk

Effects of A Dual-Task Intervention in Postural Control in Multiple Sclerosis Patients

Ffects of A Dual-Task Intervention in Postural Control in Multiple Sclerosis Patients With Low Level of Disability

The presence of postural instability is determined by a value of oscillation rate greater than 2 standard deviations from the mean of the healthy population used in this study

University Hospital, Limoges

Participants with Active Tuberculosis Disease Intervention: Diagnostic Test: VOC detection in breath and in skin headspace Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Breath sampling Intervention: Headspace analysis for biological material

Participants Without Active Tuberculosis Disease Intervention: Diagnostic Test: VOC detection in breath and in skin headspace Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Breath sampling Intervention: Headspace analysis for biological material

Patients with histologically confirmed gastric cancer Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Upper endoscopy with biopsies Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Feacal sampling Intervention: Headspace analysis for biological material Intervention: Procedure/Surgery: Histological examination of surgical speciment

Patients without gastric adenocarcinoma but with histologically confirmed dysplasia (either high- or low-grade) of the stomach Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Upper endoscopy with biopsies Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Headspace analysis for biological material Intervention: Diagnostic Test: Fecal sampling Intervention: Procedure/Surgery: Histological examination of surgical specimen

Patients graded Stage III-IV according to OLGIM (Operative Link of Gastric Intestinal Metaplasia Assessment) staging system, Stage III-IV according to OLGA (Operative Link for Gastric Atrophy Assessment), and those with incomplete type of intestinal metaplasia, but excluding those with dysplasia Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Upper endoscopy with biopsies Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Fecal sampling Intervention: Procedure/Surgery: Histological examination of surgical specimen Intervention: Headspace analysis for biological material

Staged 0-III according to OLGIM. Dysplasia should be excluded Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Upper endoscopy with biopsies Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Fecal sampling Intervention: Headspace analysis for biological material

Patients with histologically confirmed colorectal cancer (adenocarcinoma) Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Colonoscopy with biopsies Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Fecal sampling Intervention: Headspace analysis for biological material Intervention: Procedure/Surgery: Histological examination of surgical specimen

Patients without colorectal adenocarcinoma, but carrying high-risk adenomatous polyps being described by one of the following: 1) size≥1 cm; 2) high-grade dysplasia; 3) villous component. Prior to removal of the lesions Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Colonoscopy with biopsies Intervention: Headspace analysis for biological material Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Fecal sampling Intervention: Procedure/Surgery: Histological examination of surgical specimen

Patients without colorectal adenocarcinoma and without colorectal high-risk lesions Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Colonoscopy with biopsies Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Fecal sampling Intervention: Headspace analysis for biological material

Patients having undergone colonoscopy without an evidence for colorectal lesions Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Colonoscopy with biopsies Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Fecal sampling Intervention: Headspace analysis for biological material Intervention: Procedure/Surgery: Histological examination of surgical specimen

Average risk population of both genders aged 40-64 at the time of inclusion lacking alarm symptoms for gastrointestinal cancer Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Diagnostic Test: Fecal sampling Intervention: Headspace analysis for biological material

Patients with histologically confirmed pancreatic cancer Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Headspace analysis for biological material

Patients with clinically and/or histologically and/or radiologically confirmed chronic pancreatitis Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Headspace analysis for biological material

Patients with histologically confirmed primary liver cancer Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Headspace analysis for biological material

Patients with histologically confirmed liver cirrhosis of viral or other ethiology Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Headspace analysis for biological material

Patients with serologically confirmed infectious disease or individuals of high risk (e.g. population in season of flu epidemy). This group does not include tuberculosis Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Headspace analysis for biological material

Patients with histologically confirmed oncological diseases, excluding gastric, colorectal, pancreatic and primary liver cancer Intervention: Diagnostic Test: Breath sampling Intervention: Procedure/Surgery: Whole blood/ Plasma / serum sampling Intervention: Headspace analysis for biological material

Surgery and biopsy material as well as blood samples will contain himan DNA

Tuberculosis

Gastric Cancer

Peptic Ulcer

Atrophic Gastritis

Intestinal Metaplasia

Gastric Dysplasia

Colorectal Cancer

Colorectal Polyp

Colorectal Adenoma

Pancreatic Cancer

Pancreatitis, Chronic

Liver Cancer

Liver Cirrhosis

Flu, Human

Other Infectious Diseases

Inflammatory Bowel Diseases

VOC will be detected in breath with off-line and on-line testing and in skin headspace with off-line testing

VOC detection in breath and in skin headspace

Breath sampling for VOCs detections will be carried out using nano-sensor based devices (electronic nose)

Breath sampling

Upper endoscopy with proper biopsy work-up will be used for identification and stratification of gastric lesions as well as acquisition of biopsies for microbiota testing

Upper endoscopy with biopsies

Colonoscopy with proper biopsy or polypectomy material work-up will be used for identification and stratification of colorectal lesions as well as acquisition of biopsies for microbiota testing

Colonoscopy with biopsies

Whole blood/Plasma/serum sampling will be used to obtain information for group stratification

Whole blood/ Plasma / serum sampling

Facal samples will be obtained for faecal occult blood testing as well as microbiota analysis

Faecal sampling

Routine histological exam for patients undergoing curative or palliative surgery. Indication for surgery are set based on underlying condition. Study does not interfere with decision making for surgical treatment

Histological examination of surgical specimen

VOC analysis from headspace of surgical specimen, biopsy materials, blood/plasma, microbiota etc.

Headspace analysis for biological material

University of Latvia

Volatiles in Breath and Headspace Analysis - Diagnostic Markers

Volatile Organic Compounds in Breath and Headspace Analysis - Diagnostic and Monitoring Markers for Diseases

Tuberculosis specific VOC detected in breath and in skin headspace

Sensitivity, specificity, overall accuracy of nanoarray sensor testing for VOCs to detect the target lesions in the blinded analysis

List of VOCs assayed by GC-MS with statistical difference between the study groups

VOC pattern changes after specific required treatment (medical eradication of bacteria/viruses, surgery/endoscopic removal for cancers or high risk lesion)

VOC pattern changes at the time of surveillance in case of relapse (malignant diseases).

List of gastrointestinal microbiota groups (phylum/genus level) with positive correlation to particular VOCs

Technion, Israel Institute of Technology

Riga East University Hospital

JLM Innovation GmbH

Demographic and Medical History Questionnaire, Environmental Exposure Questionnaire, Food Frequency Questionnaire, Blood Sample Collection

Total 41ml sample: 17ml plasma/DNA, 10ml serum, 9ml lymphocytes and 5ml RNA frozen.

Pediatric Multiple Sclerosis

Center for pediatric-onset demyelinating diseases at the Children's Hospital of Alabama, Birmingham

Pediatric MS Clinic, Children's Hospital, Loma Linda University

UCSF Pediatric MS Center

Children's Hospital Colorado, University of Colorado School of Medicine

Pediatric MS Clinic, Children's National Medical Center

Pediatric MS Clinic, Ann & Robert H. Lurie Children's Hospital of Chicago

Partners Pediatric MS Center at the Massachusetts General Hospital for Children

Pediatric MS Clinic, Children's Hospital Boston

Regional Pediatric MS Center at Mayo Clinic

Pediatric MS Clinic, Washington University School of Medicine

Pediatric MS Center of the Jacobs Neurological Institute, University of Buffalo

New York University Langone Medical Center

The Cleveland Clinic

Pediatric MS Clinic, Children's Hospital of Philadelphia

Pediatric MS Center, University of Texas, Southwestern Medical Center

The Blue Bird Circle Clinic for MS at Texas Children's Hospital

Pediatric Neurology Clinic, Primary Children's Hospital

Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis

The primary objective of this study is to determine if risk factors identified for adult MS such as HLA-DRB1*1501/1503, EBV, 25(OH) vitamin D3 insufficiency, and exposure to cigarette smoking are also risk factors for pediatric MS, and if there are interactions between them analyzing data collected from questionnaires for environmental exposure, demographic and food frequency as well as sample blood specimens.

multiple sclerosis/nikotiin

Effects of A Dual-Task Intervention in Postural Control in Multiple Sclerosis Patients

Volatiles in Breath and Headspace Analysis - Diagnostic Markers

Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis

Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation

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