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Sepsis is defined as a systemic inflammatory response syndrome (SIRS) associated with infection diagnosed either on microbiologic cultures or strong clinical evidence of an infection..Worldwide, neonatal sepsis is responsible for 4 million deaths annually and 99% of them occur in developing
Neonatal sepsis remains one of the leading causes of morbidity and mortality both among term and preterm infants. Although advances in neonatal care have improved survival and reduced complications in preterm infants, sepsis still contributes significantly to mortality and in Neonatal Intensive Care
introduction Neonatal sepsis is an invasive bacterial infection that occurs in newborns between first and nineteenth day of life. Neonatal sepsis is one of the most frequent causes of morbidity and mortality in newborns[1]. Worldwide, incidence of sepsis in newborns varies between 1- 10 cases per
This is a randomized controlled trial. It will be provisionally conducted on 55 neonates admitted to the neonatal intensive care units (NICUs) of Ain Shams University Hospitals, Cairo, Egypt.
Inclusion criteria:
The study will include:Preterm infants (less than 37 weeks gestational age). Evidence of
1. Introduction Neonatal sepsis is a clinical syndrome of bacteremia with systemic symptoms and signs of infection in the first 28 days of life. In recent national studies, the incidence of suspected neonatal sepsis among admitted neonates varied from 32.9% to 45.9% with a higher incidence in
Study Design:
The Academic Hospital Paramaribo (AZP) has the largest perinatal care facility in Suriname. Recently, the AZP opened the country's only neonatal intensive care unit (NICU). This study aims to include all neonates presenting here and at the high and medium care facilities with clinical
Rationale Neonatal sepsis is an important determinant of adverse neurodevelopmental outcome [Adams-Chapman 2006, Stoll 2004]. A recent meta-analysis estimated that neonatal sepsis more than doubled the risk of adverse neurodevelopmental outcome in very-low-birth-weight (VLBW) infants (OR 2.09 [95%CI
1. INTRODUCTION AND RATIONALE
The live attenuated Bacillus Calmette-Guerin (BCG) vaccine protects against extrapulmonary infection with Mycobacterium tuberculosis and against leprosy [1, 2]. It has been shown that vaccination with BCG also leads to non-specific protective effects: early
Intrapartum fever (fever during labor) is a real and potentially devastating problem. Infants delivered at term who have been exposed to the mother having a fever during labor have a >9 fold increased risk of cerebral palsy. Studies have also shown an increased risk of neonatal encephalopathy
Research Design and Methods:
The study will be a multicenter, randomized, controlled, clinical trial comparing the anti-seizure effect of parenteral and/or oral labetalol (n = 4000) versus parenteral (intravenous or intramuscular) magnesium sulfate (n = 4000) with mild or severe preeclampsia who are