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Leht 1 alates 86 tulemused
2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma
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BRIEF DESCRIPTION OF THE INVENTION
The present invention relates to 2-aryl-4-hydroxy-1,3-thiazole derivatives that are useful for the prevention, reduction of the risk of, amelioration and/or treatment of diseases associated with the activity of the Transient Receptor Potential cation channel
NMDA receptor antagonists for neuroprotection
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FIELD OF THE INVENTION
The present invention is in the area of NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, as neuroprotective drugs, and includes methods and compositions for the treatment of neurodegeneration resulting from NMDA-receptor activation.
BACKGROUND OF THE
Subunit selective NMDA receptor potentiators for the treatment of neurological conditions
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FIELD OF THE INVENTION
The present invention is in the area of NMDA receptor potentiators that can be used to treat a wide range of neurological diseases and conditions, and includes methods and compositions for the treatment of neurological disorders involving NMDA-receptors.
BACKGROUND OF THE
Subunit selective NMDA receptor potentiators for the treatment of neurological conditions
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FIELD OF THE INVENTION
The present invention is in the area of NMDA receptor potentiators that can be used to treat a wide range of neurological diseases and conditions, and includes methods and compositions for the treatment of neurological disorders involving NMDA-receptors.
BACKGROUND OF THE
Benzoimidazole derivatives and pharmaceutical composition comprising the same
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TECHNICAL FIELD
The present invention relates, in general, to novel benzoimidazole derivatives and, more particularly, to novel benzoimidazole derivatives functioning as antagonists to a vanilloid receptor (capsaicin receptor; Transient Receptor Potential Channel, Vanilloid subfamily member 1;
Hydroxy-tetrahydro-naphthalenylurea derivatives
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DETAILED DESCRIPTION OF INVENTION
Technical Field
The present invention relates to a hydroxy-tetrahydro-naphthalene derivative which is useful as an active ingredient of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalene derivative of the present invention has vanilloid receptor (VR1)
Thiadiazoledioxides and thiadiazoleoxides as CXC- and CC-chemokine receptor ligands
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FIELD OF THE INVENTION
The present invention relates to novel substituted thiadiazoledioxide and thiadiazolemonooxide compounds, pharmaceutical compositions containing the compounds, and the use of the compounds and formulations in treating CXC and CC-chemokine-mediated diseases.
BACKGROUND OF THE
Thiadiazoles AS CXC- and CC- chemokine receptor ligands
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FIELD OF THE INVENTION
The present invention relates to novel substituted thiadiazole compounds, pharmaceutical compositions containing the compounds, and the use of the compounds and formulations in treating CXC and CC-chemokine-mediated diseases.
BACKGROUND OF THE INVENTION
Chemokines are
Thiadiazoles as CXC- and CC- chemokine receptor ligands
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FIELD OF THE INVENTION
The present invention relates to novel substituted thiadiazole compounds, pharmaceutical compositions containing the compounds, and the use of the compounds and formulations in treating CXC and CC-chemokine-mediated diseases.
BACKGROUND OF THE INVENTION
Chemokines are
Method for treating neurological and neuropathic diseases using rho kinase inhibitor compounds
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TECHNICAL FIELD
This invention relates to methods of preventing or treating neurological and neuropathic diseases or conditions associated with excessive inflammation, neurodegeneration, neuro-remodeling, and axonal/neurite retraction. Particularly, this invention relates to methods treating
Thiourea derivatives and the pharmaceutical compositions containing the same
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TECHNICAL FIELD
The present invention relates to novel thiourea derivatives and the pharmaceutical compositions containing the same, and particularly, to novel thiourea compounds as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions thereof. Here, the modulator means the
Isothiazole dioxides as CXC- and CC-chemokine receptor ligands
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FIELD OF THE INVENTION
The present invention relates to novel substituted isothiazole dioxide compounds, pharmaceutical compositions containing the compounds, and the use of the compounds and formulations in treating CXC and CC-chemokine-mediated diseases.
BACKGROUND OF THE INVENTION
Chemokines are
Tetrahydro-quinolinylurea derivatives
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This application is a 371 of PCT/EP2004/012051, filed Oct. 26, 2004.
DETAILED DESCRIPTION OF INVENTION
1. Technical Field
The present invention relates to a tetrahydro-quinolinylurea derivative which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-quinolinylurea
Thiourea compounds and the pharmaceutical compositions containing the same
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TECHNICAL FIELD
The present invention relates to thiourea compounds and the pharmaceutical compositions containing the same, and particularly, to thiourea compounds with superior efficacy as an antagonist against vanilloid receptor (VR) and the pharmaceutical compositions thereof.
BACKGROUND ART
As
Crystalline forms of tricyclic compound acid salt or hydrate thereof, and method for making thereof
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TECHNICAL FIELD
The present disclosure relates to novel crystalline acid salts of a tricyclic derivative or a hydrate thereof, and a production method thereof.
BACKGROUND
Drugs administered orally show medicinal effects through absorption, distribution, metabolism or elimination, and the intrinsic
Kõige täiuslikum ravimtaimede andmebaas, mida toetab teadus
- Töötab 55 keeles
- Taimsed ravimid, mida toetab teadus
- Maitsetaimede äratundmine pildi järgi
- Interaktiivne GPS-kaart - märgistage ürdid asukohas (varsti)
- Lugege oma otsinguga seotud teaduspublikatsioone
- Otsige ravimtaimi nende mõju järgi
- Korraldage oma huvisid ja hoidke end kursis uudisteuuringute, kliiniliste uuringute ja patentidega
Sisestage sümptom või haigus ja lugege ravimtaimede kohta, mis võivad aidata, tippige ürdi ja vaadake haigusi ja sümptomeid, mille vastu seda kasutatakse.
* Kogu teave põhineb avaldatud teaduslikel uuringutel
