neuralgia/oksendamine

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Leht 1 alates 66 tulemused

Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis

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Logi sisse

This invention relates to novel compounds having useful pharmacological properties, to pharmaceutical compositions containing them, to a process and intermediates for their preparation, and to their use as pharmaceuticals. UK Patent Applications, GB Nos. 2100259A and 2125398A describe benzoates and

Indolyl carboxamides useful treating migraine, cluster headache, trigeminal neuralgia or emesis

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Logi sisse

This invention relates to novel compounds having useful pharmacological properties, to pharmaceutical compositions containing them, to a process and intermediates for their preparation, and to their use as pharmaceuticals. The compound, N-(1-azabicyclo[2.2.2]oct-3-yl)-2,3-dihydroindole-1-carboxylic

Treatment of migraine, cluster headaches and trigeminal neuralgia

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Logi sisse

This invention relates to a method of treatment of migraine, cluster headaches and trigeminal neuralgia, radiation or cytotoxic agent induced nausea and vomiting and/or cardiac arrhythmia in mammals, including humans, and to the use of compounds in the preparation of a medicament for the treatment

Benzoimidazole derivatives and pharmaceutical composition comprising the same

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Logi sisse

TECHNICAL FIELD The present invention relates, in general, to novel benzoimidazole derivatives and, more particularly, to novel benzoimidazole derivatives functioning as antagonists to a vanilloid receptor (capsaicin receptor; Transient Receptor Potential Channel, Vanilloid subfamily member 1;

Azabicyclic amine derivatives and their use as therapeutic agents

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Logi sisse

CROSS REFERENCE TO RELATED APPLICATIONS This application claims priority under 35 U.S.C. .sctn.119 from GB Application No. 0108971.3, filed Apr. 10, 2001. The present invention provides compounds of the formula (I): ##STR2## wherein X represents hydrogen or a C.sub.1-4 alkyl group optionally

Tetrahydropyran derivatives and their use as therapeutic agents

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Logi sisse

This invention relates to a class of tetrahydropyran compounds which are useful as tachykinin antagonists. More particularly, the compounds of the invention are useful as neurokinin 1 (NK-1) receptor antagonists. By virtue of their excellent specificity for the human NK-1 receptor, the compounds of

Morpholine derivatives and their use as therapeutic agents

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Logi sisse

This invention relates to a class of morpholine derivatives which are useful as tachykinin antagonists. The tachykinins are a group of naturally occurring peptides found widely distributed throughout mammalian tissues, both within the central nervous system and in peripheral nervous and circulatory

Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines

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Logi sisse

U.S. Provisional Application No. 61/259,138, filed Nov. 7, 2009. BACKGROUND OF THE INVENTION (1) Field of Invention Treatment of Fibrocystic Disease of Breast (2) Description of Related Art CITATIONS Cuscela, Daniel, et al. "Protection from Radiation-Induced Alopecia with Topical Application of

Spirocyclic ketones and their use as tachykinin antagonists

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Logi sisse

This invention relates to a class of spirocyclic ketone compounds which are useful as tachykinin antagonists. More particularly, the compounds of the invention are 3-spiro-cyclopentanone piperidine derivatives. International (PCT) patent specification no. WO 97/49710 (published Dec. 31st, 1997)

2-aryl indole derivative as antagonists of tachykinins

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Logi sisse

This invention relates to indole derivatives and their use as tachykinin antagonists, and in particular as neurokinin-1 receptor antagonists. We have now found a class of indole derivatives which are potent receptor antagonists of tachykinins, especially of the neurokinin-1 (substance P)

Sulphonamide derivatives, their preparation and their therapeutic application

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Logi sisse

FIELD OF THE INVENTION The present invention relates to sulfonamide derivatives, to the process for preparing them and to their therapeutic use. BACKGROUND OF THE INVENTION Orexins A and B (or hypocretins 1 and 2) are hypothalamus neuropeptides of 33 and 28 amino acids, respectively, recently

Spiro-piperidine derivatives and their use as tachykinin antagonists

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Logi sisse

This invention relates to a class of azacyclic compounds which are useful as tachykinin antagonists. More particularly, the compounds of the invention are spiro-substituted azacyclic derivatives. The tachykinins are a group of naturally occurring peptides found widely distributed throughout

Biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same

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Logi sisse

TECHNICAL FIELD The present invention relates to a novel biaryl benzoimidazole derivative, a method for preparing the same, and a pharmaceutical composition comprising the same, in which the biaryl benzoimidazole derivative functions as an antagonist of the vanilloid receptor (Capsaicin receptor;

Benzimidazolone derivatives as CB2 receptor ligands

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Logi sisse

BACKGROUND OF THE INVENTION This invention relates to benzimidazolone derivatives. These compounds have selective cannabinoid(CB)2 receptor binding activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives for the

Sulfonyl benzimidazole derivatives

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Logi sisse

BACKGROUND OF THE INVENTION This invention relates to sulfonyl benzimidazole derivatives. These compounds have selective cannabinoid (CB)2 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives

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