neurogenic inflammation/oksendamine

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Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).

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Logi sisse

Activation of vanilloid receptors has commonly been used to facilitate neurogenic inflammation and plasma exudation to model components of the pathogenesis of migraine; however, these studies have been performed mainly in species lacking the emetic reflex. In the present studies, therefore, we used

Symptomatology and pathogenesis of migraine.

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Logi sisse

Migraine is a paroxysmal disorder of which headache is the central symptom. The headache is generally so intense that it is associated with other symptoms, such as nausea, vomiting, photo- and phonophobia. In so-called classic migraine or migraine with aura, the headache is preceded by transient

Symptomatic and prophylactic treatment of migraine: a critical reappraisal.

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Logi sisse

The pharmacologic management of migraine has traditionally focused on two approaches: symptomatic treatment and prophylactic therapy. The objective of symptomatic treatment is to reduce the intensity and duration of pain with its attendant symptoms and to optimize the patient's ability to function

Biochemistry, Substance P

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Logi sisse

Substance P is a neuropeptide made up of 11 amino acids—an undecapeptide—and is a part of the tachykinin neuropeptide family. Its receptor, neurokinin type 1 (NK-1R), is a transmembrane bound receptor on many cell types in the body including the endothelium of the blood vessels and lymphatics, white

Periodontal disease as a potential factor of migraine chronification.

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Logi sisse

Migraine is a hereditary constitutional base disorder, which is characterized by recurrent episodes of headache pulsatile characteristics associated with photophobia/phonophobia, nausea and/or vomiting. The main complication in migraine is the chronicity of the process, now recognized as a chronic

Substance P antagonists as a therapeutic approach to improving outcome following traumatic brain injury.

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Logi sisse

Although a number of secondary injury factors are known to contribute to the development of morphological injury and functional deficits following traumatic brain injury, accumulating evidence has suggested that neuropeptides, and in particular substance P, may play a critical role. Substance P is

Pathogenesis and clinical and economic consequences of postoperative ileus.

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Logi sisse

Postoperative ileus (POI) occurs frequently in patients undergoing major abdominal surgery; and only recently has there been renewed interest in understanding the pathogenesis, etiology, clinical manifestations, and clinical and economic consequences related to POI. This interest has been spurred by

Biological and Pharmacological Aspects of the NK1-Receptor.

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Logi sisse

The neurokinin 1 receptor (NK-1R) is the main receptor for the tachykinin family of peptides. Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is associated with multiple processes: hematopoiesis, wound healing, microvasculature permeability, neurogenic

Emerging pharmacologic options for treating postoperative ileus.

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Logi sisse

OBJECTIVE Characteristics of the ideal drug therapy for postoperative ileus (POI); the pharmacology, efficacy, and safety of currently available nonselective opioid antagonists and the new peripherally selective opioid antagonists methylnaltrexone and alvimopan for the treatment of POI; and

Neurokinin-receptor antagonists: pharmacological tools and therapeutic drugs.

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Logi sisse

The mammalian tachykinins (substance P, neurokinin A, and neurokinin B) are widely distributed throughout the central and peripheral nervous systems, where they act as neurotransmitters or neuromodulators. Historically, the tachykinins have been implicated in a wide variety of biological actions

Pathogenesis and clinical and economic consequences of postoperative ileus.

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Logi sisse

OBJECTIVE The pathogenesis, etiology, clinical manifestations, and clinical and economic consequences of postoperative ileus (POI) in patients undergoing major abdominal surgery; the estimated prevalence of POI; the potential cost savings from efforts to shorten hospital length of stay (LOS); and

Substance P and the Neurokinin-1 Receptor: The New CRF.

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Logi sisse

Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and sequenced 40 years later, SP has been extensively studied. Early studies identified a role for SP and the NK1R in contraction of

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