Intracranial Hypertension

Cerebral Circulatory Failure

Noninvasive devices are been used to assess cerebral circulation and compliance.

Cerebral compliance and hemodynamics monitoring

Hospital das Clínicas da Faculdade de Medicina da USP.

Cerebral Compliance Impairment in COVID-19

Assessment of Cerebral Compliance and Hemodynamics in Severe COVID-19

Observe alteration in cerebral compliance due to potential intracranial hypertension during severe COVID-19. This situation is indicated when the relation P2/P1 given by the B4C sensor is >1.

Observe disturbances in cerebral circulation during severe COVID-19, given by blood flow velocities in middle cerebral arteries (with normal range 40-70 cm/s) and the pulsatility index (normal <1.2) calculated by transcranial Doppler.

Observe whether disturbances in cerebral compliance and hemodynamics assessed in this population is significantly associated with higher mortality.

Sergio Brasil, MD

Principal investigator

University of Sao Paulo

Irradiation of the lungs, administered in a single fraction at the average prescription dose of 0.7 Gy

COVID-19

Participants will undergo irradiation of the lungs, administered in a single fraction at the average prescription dose of 0.7 Gy

Single fraction whole lung radiotherapy

Radiation Oncology Department, ASST SpedaliCivili, Brescia

COVID-19 Pneumonitis Low Dose Lung Radiotherapy (COLOR-19)

Pilot Study on the Feasibility of Low Dose Radiotherapy for SARS-Cov-2 Pneumonitis (COVID-19 Low Dose Radiotherapy - COLOR 19)

Evaluation of the feasibility of low-dose radiotherapy treatment of SARS-Cov2 pneumonia, for the purpose of the subsequent implementation of a phase II study; lenght of hospital stay will be recorded

Evaluation of the feasibility of low-dose radiotherapy treatment of SARS-Cov2 pneumonia; the number of intensive care unit admissions will be recorded

Variation of the patient's score according to the Brescia COVID-19 Respiratory Severity Scale (minimum value 0, maximum value 8; higher scores mean a worse outcome) with baseline, assessed at 3, 6 and 10 days after treatment.

Evaluation of the safety and tolerance of the low-dose radiotherapy treatment of SARS-Cov2 ( using the CTCAE 5.0 scale)

Variation of the radiological findings, assessed by chest X-ray (performed 3 and 6 days after treatment) and defined according to the Brixia scoring system (0-18 scale, with 18 meaning the worse outcome)

All Individual Participant Data that underlie results in the publication

Stefano Maria Magrini

Prof

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

COVID

GastroMuñoz

COVID-EC Study: Clinical Characteristics of Patients With COVID-19 in Guayaquil, Ecuador

Clinical Characteristics of Patients With SARS-CoV-2 (COVID-19) Infection in Guayaquil, Ecuador: COVID-EC Study

To know the clinical characteristics of patients with COVID-19 treated in hospitals in Guayaquil, Ecuador.

Establish the prognosis of patients, in terms of need for admission to intensive care, use of mechanical ventilation or death.

To determine the clinical characteristics of the patients with the worst prognosis.

Relate, at least retrospectively, the relationship that may exist between the different treatments and the prognosis.

olfaction disorders/turse

Cerebral Compliance Impairment in COVID-19

COVID-19 Pneumonitis Low Dose Lung Radiotherapy (COLOR-19)

COVID-EC Study: Clinical Characteristics of Patients With COVID-19 in Guayaquil, Ecuador

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