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Antitumor effect of palmitoleic acid on Ehrlich ascites tumor.

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Palmitoleic acid (PLOA) markedly prolonged the survival time of mice bearing Ehrlich ascites tumor at doses of 37.5-150 mg/kg/day X 10, but the antitumor activity of oleic acid (OA) was weaker than that of PLOA. The total lipid and phospholipid contents in the tumor cells treated with PLOA were

Fatty acid proportions in cholesterol esters and risk of premature death from cancer in middle aged French men.

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OBJECTIVE To assess the association of proportions of fatty acids in cholesterol esters with the risk of premature death from cancer in middle aged men. METHODS Prospective cohort study. METHODS Paris, France. METHODS 3277 working men aged 36-52 in 1981-5. METHODS Cancer mortality during an average

Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease.

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BACKGROUND Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle. OBJECTIVE To evaluate the consumption of fatty

Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer.

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Ecological and case-control studies have demonstrated a positive correlation between consumption of fat and the risk of prostate cancer. Two recent human studies have focused on alpha-linolenic acid as a risk factor for prostate cancer. Animal experiments have shown that dietary omega-6

Cytotoxic effects of free fatty acids on ascites tumor cells.

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The effect of physiologic common free fatty acids (FFAs) on Mat 1376b ascites tumor cells in vitro and in vivo in F344 rats was investigated. Unsaturated fatty acids, such as palmitoleic (16:1), oleic (18:1), linoleic (18:2), linolenic (18:3), and arachidonic (20:4) acids, were significantly more

Effects of fatty acid modification of ascites tumor cells on pulmonary metastasis in rat.

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Yoshida sarcoma cells were incubated with each of 4 different saturated and 17 different unsaturated fatty acid methyl and ethyl esters in order to modify the fatty acid composition of the cell membrane, and a possible correlation between the lipid fluidity of the cell membrane and the metastatic

Palmitoleic acid reduces the inflammation in LPS-stimulated macrophages by inhibition of NFκB, independently of PPARs.

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Palmitoleic acid (PM, 16:1n-7) has anti-inflammatory properties that could be linked to higher expression of PPARα, an inhibitor of NFκB. Macrophages play a major role in the pathogenesis of chronic inflammation, however, the effects of PM on macrophages are underexplored. Thus, we aimed to

Palmitoleic Acid has Stronger Anti-Inflammatory Potential in Human Endothelial Cells Compared to Oleic and Palmitic Acids.

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Fatty acids (FAs) may affect endothelial cell (EC) function, influencing atherogenesis and inflammatory processes. Palmitoleic acid (POA) has been described as an anti-inflammatory FA. However, its effects on ECs are underexplored. This study compares the effects of POA with those of palmitic acid

GC-MS Metabolomics Reveals Distinct Profiles of Low- and High-Grade Bladder Cancer Cultured Cells.

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Previous studies have shown that metabolomics can be a useful tool to better understand the mechanisms of carcinogenesis; however, alterations in biochemical pathways that lead to bladder cancer (BC) development have hitherto not been fully investigated. In this study, gas chromatography-mass

Relationship between plasma fatty acid composition and diet over previous years in the Italian centers of the European Prospective Investigation into Cancer and Nutrition (EPIC).

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Fatty acid levels in plasma phospholipids were related to food intake over the previous year as estimated by semiquantitative food frequency questionnaires compiled by 280 men and 246 women from the EPIC centers of Varese, Turin, Florence and Ragusa (Italy). Fatty acid content was determined by gas

Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population.

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BACKGROUND Fatty acid (FA) composition in serum has been associated with C-reactive protein (CRP), but associations with other markers of inflammation and endothelial function, e.g. adhesion molecules are unknown. We recently suggested a possible role of the lipogenic enzyme stearoyl coenzymeA

Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity.

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Non-alcoholic fatty liver disease (NAFLD) as a global health problem has clinical manifestations ranging from simple non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis, and cancer. The role of different types of fatty acids in driving the early progression of NAFL to

Eicosanoid synthesis in 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in Sprague-Dawley rats fed primrose oil, menhaden oil or corn oil diet.

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The comparative effects of high-fat diets (20%, w/w) on eicosanoid synthesis during mammary tumor promotion in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rats were studied using diets containing 20% primrose oil (PO), 20% menhaden oil (MO) or 20% corn oil (CO). Sprague-Dawley rats fed the PO or

Dietary lipid and iron modify normal colonic mucosa without affecting phospholipase A2 activity.

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Phospholipase A2 (PLA2) functions as the rate-limiting step in arachidonic acid metabolism and in the removal of damaged or peroxidized membrane lipids. It is elevated in some human tumors and may be involved with mechanisms of tumor promotion. In vitro systems have shown PLA2 activity to be altered

Effect of high fat corn oil, olive oil and fish oil on phospholipid fatty acid composition in male F344 rats.

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Epidemiological and laboratory animal model studies have provided evidence that the effect of dietary fat on colon tumorigenesis depends on the amount of fat and its composition. Because of the importance of the composition of dietary fat and of tissue membrane fatty acid composition in tumor

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